Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast

被引：21

作者：

Legakis, Ioannis ^{[1
]}

Mantzouridis, Timos ^{[2
]}

Bouboulis, George ^{[3
]}

Chrousos, George P. ^{[4
]}

机构：

[1] Iaso Gen Hosp, Athens, Greece

[2] Euromed High Technol SA, Athens, Greece

[3] Aretaie Univ Hosp, Athens Med Sch, Athens, Greece

[4] Univ Athens, Sch Med, Dept Pediat 1, GR-11527 Athens, Greece

来源：

ARCHIVES OF ENDOCRINOLOGY METABOLISM | 2016年 / 60卷 / 01期

关键词：

Adipsin; visfatin; type; 2; diabetes; fasting; humans; METAANALYSIS; ADIPOKINE; ADIPSIN; IMPACT;

D O I：

10.1590/2359-3997000000147

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: In order to elucidate the interrelationship of adipokines in glucose hemiostasis, we determined the concentration of visfatin and adipsin in blood samples in patients with type 2 diabetes and age-matched controls after an overnight fast. Subjects and methods: We enrolled 37 patients with known type 2 diabetes -21 males and 16 females, aged 62.95 +/- 15.72 years and 43 controls- 28 males and 15 females, aged 60.79 +/- 12.67 years. Blood samples were collected after an overnight fast and routine biochemical parameters such as glucose, cholesterol, HDL, LDL, triglycerides along with Hb1Ac, insulin and c-peptide, in addition to circulating visfatin and adipsin were determined in all samples. Data were considered significant at a level of p < 0.05. Results: In patients with type 2 diabetes, circulating adipsin levels were decreased and inversely related with glucose levels while circulating visfatin was increased significantly in the fasting state. Conclusion: These results implicate the adipokines adipsin and visfatin as possible participants in the pathogenesis of type 2 diabetes.

引用

页码：76 / 78

页数：3

共 9 条

[1] Visceral Adiposity Index (VAI) Is Predictive of an Altered Adipokine Profile in Patients with Type 2 Diabetes [J].