Diagnostic accuracy of CSF neurofilament light chain protein in the biomarker-guided classification system for Alzheimer's disease

被引：46

作者：

Lista, Simone ^{[1
,2
]}

Toschi, Nicola ^{[3
,4
,5
]}

Baldacci, Filippo ^{[1
,2
,6
]}

Zetterberg, Henrik ^{[7
,8
]}

Blennow, Kaj ^{[7
,9
]}

Kilimann, Ingo ^{[10
,11
]}

Teipel, Stefan J. ^{[10
,11
]}

Cavedo, Enrica ^{[1
,2
,12
]}

dos Santos, Antonio Melo ^{[13
]}

Epelbaum, Stephane ^{[13
]}

Lamari, Foudil ^{[14
]}

Dubois, Bruno ^{[13
]}

Floris, Roberto ^{[3
]}

Garaci, Francesco ^{[3
,15
]}

Hampel, Harald ^{[1
,2
]}

机构：

[1] AXA Res Fund, Blvd Hop, F-75013 Paris, France

[2] Univ Pierre & Marie Curie UPMC Paris 06, Sorbonne Univ, UPMC Chair,DeptNeurol, Hop Pitie Salpetriere,IM2A,INSERM,CNRS,Inst Cerve, Blvd Hop, F-75013 Paris, France

[3] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy

[4] Athinoula A Martinos Ctr Biomed Imaging, Dept Radiol, Boston, MA USA

[5] Harvard Med Sch, Boston, MA USA

[6] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

[7] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden

[8] UCL Inst Neurol, Dept Mol Neurosci, Queen Sq, London, England

[9] Royal Swedish Acad Sci, Torsten Soderberg Professorship Med, Stockholm, Sweden

[10] Univ Rostock, Dept Psychosomat Med, Rostock, Germany

[11] DZNE Rostock, Rostock, Germany

[12] IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy

[13] Univ Pierre & Marie Curie UPMC Paris 06, Sorbonne Univ, Hop Pitie Salpetriere, INSERM,CNRS,IM2A,Dept Neurol,Inst Cerveau & Moell, Blvd Hop, F-75013 Paris, France

[14] Grp Hosp Pitie Salpetriere, AP HP, Serv Biochim Metab, UF Biochem Malad Neurometab, Paris, France

[15] Casa di Cura San Raffaele Cassino, Cassino, Italy

来源：

NEUROCHEMISTRY INTERNATIONAL | 2017年 / 108卷

关键词：

Neurofilament light chain protein; Alzheimer's disease pathophysiology; Frontotemporal dementia; Mild cognitive impairment; Biomarkers; Cerebrospinal fluid; CEREBROSPINAL-FLUID; FRONTOTEMPORAL DEMENTIA; NATIONAL INSTITUTE; ASSOCIATION; DEGENERATION; GUIDELINES; CRITERIA; BRAIN;

D O I：

10.1016/j.neuint.2017.05.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We assessed the diagnostic accuracy of cerebrospinal fluid (CSF) neurofilament light chain (NFL) protein in the classification of patients with Alzheimer's disease (AD) and cognitively healthy control individuals (HCs) and patients with frontotemporal dementia (FTD) as comparisons. Particularly, we tested the performance of CSF NFL concentration in differentiating patient groups stratified by fluid biomarker profiles, independently of the severity of cognitive impairment (mild cognitive impairment (MCI) and AD dementia individuals), using a biomarker-guided descriptive classification system for AD. CSF NFL concentrations were examined in a multicenter cross-sectional study of 108 participants stratified in AD pathophysiology-negative (both CSF tau and the 42-amino acid-long amyloid-beta (A beta) peptide (A beta(1-42))) (n = 15), tau pathology-positive only (n = 15), A beta pathology-positive only (n = 13), AD pathophysiology-positive (n = 33), FTD (n = 9) patients, and HCs (n = 23), according to the biomarker-based classification system. The performance of CSF NFL in discriminating AD pathophysiology-positive patients from HCs is fair, whereas the ability in differentiating tau-positive patients from HCs is poor. The classificatory performance in distinguishing AD pathophysiology-positive patients from FTD is unsatisfactory. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：355 / 360

页数：6