A concise study on dimedone: A versatile molecule in multi-component reactions, an outlook to the green reaction media

Dimedone is an interesting and versatile motif in most organic transformations. Its white to light yellow crystals have been utilized as substrate in wide range of organic reactions including multi-component transformations. The notability of dimedone is due to the acidic property of its methylene group which is in equilibrium with its tautomeric enol form. This phenomena permit dimedone to be utilized in several kinds of organic reactions eventuated to several organic molecules with potent pharmaceutical exclusivity. The mentioned nature of dimedone in addition with its low toxicity, easily accessibility and handling, moisture stability, and low cost make it interesting for organic chemists. During the last decades, perfuming an organic transformation based on green chemistry rules, is in demand. In this review the reactions of dimedone has been focused with an outlook to the solvent of media. Each section has been subdivided respect to the temperature of the transformations. All categorizations has been accomplished to the green media. The authors has also calculated the atom economy of each reaction on behalf of green chemistry concept. (C) 2017 King Saud University. Production and hosting by Elsevier B.V.