Recurrence after Treatment for Pulmonary Multidrug-Resistant Tuberculosis

被引：23
作者：
Becerra, Mercedes C. [1 ,2 ]
Appleton, Sasha C. [1 ,2 ,3 ]
Franke, Molly F. [1 ,2 ]
Chalco, Katiuska [2 ]
Bayona, Jaime [1 ,2 ]
Murray, Megan B. [3 ,4 ]
Mitnick, Carole D. [1 ,2 ]
机构：
[1] Harvard Univ, Sch Med, Dept Global Hlth & Social Med, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Socios Salud Sucursal Peru Partners Hlth, Boston, MA 02115 USA
[3] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[4] Brigham & Womens Hosp, Div Global Hlth Equ, Boston, MA 02115 USA
来源：
CLINICAL INFECTIOUS DISEASES | 2010年 / 51卷 / 06期
基金：
比尔及梅琳达.盖茨基金会;
关键词：
FOLLOW-UP;
D O I：
10.1086/655892
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We estimated the proportion of recurrence within 2 years among adults cured by individualized multidrug-resistant tuberculosis regimens in Peru. Among 310 individuals with at least 24 months of follow-up, 16 experienced an episode of recurrent tuberculosis. If we assume the worst for treatment effectiveness-that all 16 episodes were caused by the original tuberculosis strain-then 5.2% (95% confidence interval, 3.0%-8.2%) experienced true relapse. This is an upper-bound estimate of relapse on which new regimens must improve.
引用
收藏
页码：709 / 711
页数：3
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