Turning blood into brain:: Cells bearing neuronal antigens generated in vivo from bone marrow

被引:1406
作者
Mezey, É [1 ]
Chandross, KJ
Harta, G
Maki, RA
McKercher, SR
机构
[1] NINDS, Basic Neurosci Program, NIH, Bethesda, MD 20892 USA
[2] NINDS, Lab Dev Neurogenet, NIH, Bethesda, MD 20892 USA
[3] Burnham Inst, La Jolla, CA 92037 USA
[4] Neurocrine Biosci, San Diego, CA 92121 USA
关键词
D O I
10.1126/science.290.5497.1779
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Bone marrow stern cells give rise to a variety of hematopoietic Lineages and repopulate the blood throughout adult Life. We show that, in a strain of mice incapable of developing colts of the myeloid and Lymphoid lineages,transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury.
引用
收藏
页码:1779 / 1782
页数:4
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