Sphingolipids in metabolic disease: The good, the bad, and the unknown

被引：194

作者：

Green, Christopher D. ^{[1
,2
]}

Maceyka, Michael ^{[1
,2
]}

Cowart, L. Ashley ^{[1
,2
,3
]}

Spiegel, Sarah ^{[1
,2
]}

机构：

[1] VCU Sch Med, Dept Biochem & Mol Biol, Richmond, VA 23298 USA

[2] Massey Canc Ctr, Richmond, VA 23298 USA

[3] Hunter Holmes McGuire VA Med Ctr, Richmond, VA 23298 USA

来源：

CELL METABOLISM | 2021年 / 33卷 / 07期

基金：

美国国家卫生研究院;

关键词：

SPHINGOSINE KINASE 1; AMELIORATES HEPATIC STEATOSIS; INDUCED INSULIN-RESISTANCE; MUSCLE CERAMIDE CONTENT; CONFERS SUSCEPTIBILITY; GLUCOSE-TOLERANCE; ADIPOSE-TISSUE; FATTY-ACIDS; RECEPTOR; DIET;

D O I：

10.1016/j.cmet.2021.06.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) are a recent addition to the lipids accumulated in obesity and have emerged as important molecular players in metabolic diseases. Here we summarize evidence that dysregulation of sphingolipid metabolism correlates with pathogenesis of metabolic diseases in humans. This review discusses the current understanding of how ceramide regulates signaling and metabolic pathways to exacerbate metabolic diseases and the Janus faces for its further metabolite S1P, the kinases that produce it, and the multifaceted and at times opposing actions of S1P receptors in various tissues. Gaps and limitations in current knowledge are highlighted together with the need to further decipher the full array of their actions in tissue dysfunction underlying metabolic pathologies, pointing out prospects to move this young field of research toward the development of effective therapeutics.

引用

页码：1293 / 1306

页数：14

共 121 条

[1] Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2 [J].

Aji, Gulibositan ;

Huang, Yu ;

Li Ng, Mei ;

Wang, Wei ;

Lan, Tian ;

Li, Min ;

Li, Yufei ;

Chen, Qi ;

Li, Rui ;

Yan, Sishan ;

Tran, Collin ;

Burchfield, James G. ;

Couttas, Timothy A. ;

Chen, Jinbiao ;

Chung, Long Hoa ;

Liu, Da ;

Wadham, Carol ;

Hogg, Philip J. ;

Gao, Xin ;

Vadas, Mathew A. ;

Gamble, Jennifer R. ;

Don, Anthony S. ;

Xia, Pu ;

Qi, Yanfei .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (39) :24434-24442

[2] Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease [J].

Al Fadel, Frdoos ;

Fayyaz, Susann ;

Japtok, Lukasz ;

Kleuser, Burkhard .

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2016, 40 (06) :1637-1645

[3] De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis [J].

Alexaki, Aikaterini ;

Clarke, Benjamin A. ;

Gavrilova, Oksana ;

Ma, Yinyan ;

Zhu, Hongling ;

Ma, Xinran ;

Xu, Lingyan ;

Tuymetova, Galina ;

Larman, Bridget C. ;

Allende, Maria L. ;

Dunn, Teresa M. ;

Proia, Richard L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (09) :3929-3939

[4] Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells [J].

An, Dingding ;

Oh, Sungwhan F. ;

Olszak, Torsten ;

Neves, Joana F. ;

Avci, Fikri Y. ;

Erturk-Hasdemir, Deniz ;

Lu, Xi ;

Zeissig, Sebastian ;

Blumberg, Richard S. ;

Kasper, Dennis L. .

CELL, 2014, 156 (1-2) :123-133

[5] Depletion of adipocyte sphingosine kinase 1 leads to cell hypertrophy, impaired lipolysis, and nonalcoholic fatty liver disease [J].

Anderson, Andrea K. ;

Lambert, Johana M. ;

Montefusco, David J. ;

Tran, Bao Ngan ;

Roddy, Patrick ;

Holland, William L. ;

Cowart, L. Ashley .

JOURNAL OF LIPID RESEARCH, 2020, 61 (10) :1328-1340

[6] Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients [J].

Anroedh, Sharda ;

Hilvo, Mika ;

Akkerhuis, K. Martijn ;

Kauhanen, Dimple ;

Koistinen, Kaisa ;

Oemrawsingh, Rohit ;

Serruys, Patrick ;

van Geuns, Robert-Jan ;

Boersma, Eric ;

Laaksonen, Reijo ;

Kardys, Isabella .

JOURNAL OF LIPID RESEARCH, 2018, 59 (09) :1729-1737

[7] Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions [J].

Bandet, Cecile L. ;

Mahfouz, Rana ;

Veret, Julien ;

Sotiropoulos, Athanassia ;

Poirier, Maxime ;

Giussani, Paola ;

Campana, Melanie ;

Philippe, Erwann ;

Blachnio-Zabielska, Agnieszka ;

Ballaire, Raphaelle ;

Le Liepvre, Xavier ;

Bourron, Olivier ;

Berkes, Dusan ;

Gorski, Jan ;

Ferre, Pascal ;

Le Stunff, Herve ;

Foufelle, Fabienne ;

Hajduch, Eric .

DIABETES, 2018, 67 (07) :1258-1271

[8] Identification of a Metabolic, Transcriptomic, and Molecular Signature of Patatin-Like Phospholipase Domain Containing 3-Mediated Acceleration of Steatohepatitis [J].

Banini, Bubu A. ;

Kumar, Divya P. ;

Cazanave, Sophie ;

Seneshaw, Mulugeta ;

Mirshahi, Faridoddin ;

Santhekadur, Prasanna K. ;

Wang, Liangsu ;

Guan, Hong Ping ;

Oseini, Abdul M. ;

Alonso, Cristina ;

Bedossa, Pierre ;

Koduru, Srinivas V. ;

Min, Hae-Ki ;

Sanyal, Arun J. .

HEPATOLOGY, 2021, 73 (04) :1290-1306

[9] Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans [J].

Bergman, Bryan C. ;

Brozinick, Joseph T. ;

Strauss, Allison ;

Bacon, Samantha ;

Kerege, Anna ;

Bui, Hai Hoang ;

Sanders, Phil ;

Siddall, Parker ;

Wei, Tao ;

Thomas, Melissa K. ;

Kuo, Ming Shang ;

Perreault, Leigh .

DIABETOLOGIA, 2016, 59 (04) :785-798

[10] Endothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR247799, in type-2 diabetes rats and a randomized placebo-controlled patient trial [J].

Bergougnan, Luc ;

Andersen, Grit ;

Plum-Moerschel, Leona ;

Evaristi, Maria Francesca ;

Poirier, Bruno ;

Tardat, Agnes ;

Ermer, Marcel ;

Herbrand, Theresa ;

Arrubla, Jorge ;

Coester, Hans Veit ;

Sansone, Roberto ;

Heiss, Christian ;

Vitse, Olivier ;

Hurbin, Fabrice ;

Boiron, Rania ;

Benain, Xavier ;

Radzik, David ;

Janiak, Philip ;

Muslin, Anthony J. ;

Hovsepian, Lionel ;

Kirkesseli, Stephane ;

Deutsch, Paul ;

Parkar, Ashfaq A. .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021, 87 (05) :2303-2320

← 1 2 3 4 5 6 7 8 9 10 →