Advances in the Prediction and Natural History of Type 1 Diabetes

被引：39
作者：
Bonifacio, Ezio [1 ]
Ziegler, Anette G. [2 ]
机构：
[1] Tech Univ Dresden, Deutsch Forschungsgemeinschaft Ctr Regenerat Ther, D-01307 Dresden, Germany
[2] Tech Univ Munich, Klinikum Rechts Isar, Forschergrp Diabet, D-80804 Munich, Germany
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2010年 / 39卷 / 03期
关键词：
Type; 1; diabetes; Autoantibodies; Islet autoimmunity; ISLET-CELL-ANTIBODIES; AUTOREACTIVE T-CELLS; GENERAL-POPULATION; INSULIN-RESISTANCE; STANDARDIZATION PROGRAM; 1ST-DEGREE RELATIVES; INTERVENTION TRIAL; POSITIVE RELATIVES; GENETIC RISK; AUTOANTIBODIES;
D O I：
10.1016/j.ecl.2010.05.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Type 1 diabetes (T1D) has the hallmark characteristics of autoimmunity superimposed on genetic susceptibility. Both genes (HLA) and immune markers (autoantibodies) have been validated as predictive markers of the subsequent development of the disease in higher-risk relatives and the lower-risk general population. Over the last three decades, using a combination of genes, immune, and metabolic markers, clinicians are now able to quantify an individual's disease risk from 1 in 100,000 to more than 1 in 2. This article reviews these biomarkers and T1D prediction strategies, and discusses potential implications of prediction and natural history for the pathogenesis of T1D.
引用
收藏
页码：513 / +
页数：15
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