Pseudoginsenoside-F11 decreases morphine-induced behavioral sensitization and extracellular glutamate levels in the medial prefrontal cortex in mice

被引：33

作者：

Hao, Yue ^{[1
]}

Yang, Jing Yu ^{[1
]}

Wu, Chun Fu ^{[1
]}

Wu, Min Fan ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2007年 / 86卷 / 04期

关键词：

morphine; pseudoginsenoside-F11; behavioral sensitization; medial prefrontal cortex; glutamate; microdialysis;

D O I：

10.1016/j.pbb.2007.02.011

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Morphine produces a variety of behavioral and biochemical changes related to its abuse. Our previous studies showed that Pseudoginsenoside-F11 (PF 11), an ocotillol-type saponin existing in American ginseng, can antagonize pharmacological effects of morphine. To further investigate the effects of PF 11 on morphine abuse and the underlying mechanisms, we tested the effects of PF 11 on morphine-induced development of behavioral sensitization and alterations in glutamate levels in the medial prefrontal cortex (mPFC) in freely moving mice by using in vivo microdialysis. As the results shown, PF 11 antagonized the development of behavioral sensitization and decrease of glutamate in the mPFC induced by morphine. Therefore, these findings suggest that PF 11 may block the development of morphine-induced behavioral sensitization via its effect, at least partially, on the glutamatergic system in the mPFC. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：660 / 666

页数：7

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