Dermoscopy structures as predictors of sentinel lymph node positivity in cutaneous melanoma

被引：15

作者：

Gonzalez-Alvarez, T. ^{[1
,6
]}

Carrera, C. ^{[1
,7
]}

Bennassar, A. ^{[1
]}

Vilalta, A. ^{[1
]}

Rull, R. ^{[2
]}

Alos, L. ^{[3
,8
]}

Palou, J. ^{[1
]}

Vidal-Sicart, S. ^{[4
,5
]}

Malvehy, J. ^{[1
,7
]}

Puig, S. ^{[1
,7
,8
]}

机构：

[1] Hosp Clin Barcelona, Dept Dermatol, Barcelona, Spain

[2] Hosp Clin Barcelona, Surg Serv, Barcelona, Spain

[3] Hosp Clin Barcelona, Pathol Serv, Barcelona, Spain

[4] Hosp Clin Barcelona, Nucl Med Serv, Melanoma Unit, Barcelona, Spain

[5] IDIBAPS Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain

[6] Univ CES, Medellin, Colombia

[7] ISCIII, CIBERER, Barcelona, Spain

[8] Univ Barcelona, Dept Med, Barcelona, Spain

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2015年 / 172卷 / 05期

关键词：

HIGH-FREQUENCY SONOGRAPHY; MALIGNANT-MELANOMA; MITOTIC RATE; PREOPERATIVE EVALUATION; PROGNOSTIC FACTORS; REGIONAL NODES; BIOPSY; THICKNESS; ULCERATION; SURVIVAL;

D O I：

10.1111/bjd.13552

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background Histological features such as Breslow thickness, ulceration and mitosis are the main criteria to guide sentinel lymph node biopsy (SLNB) in melanoma. Dermoscopy may add complementary information to these criteria. Objectives To evaluate the correlation between dermoscopy structures and SLNB positivity. Methods Retrospective analysis of 123 consecutive melanomas with Breslow thickness > 0.75 mm, SLNB performed during follow-up and dermoscopic images. Results Men were more likely to have a positive SLNB. The presence of ulceration and blotch and the absence of a pigmented network in dermoscopy correlated with positive SLNB. Histological ulceration also correlated with positive SLNB. A dermoscopy SCORE predicted SLN status with a sensitivity of 96.3% and a specificity of 30.2%. When sex and Breslow thickness were added (SCOREBRESEX), the sensitivity remained at 96.3% but the specificity increased to 52.1%. This study is limited by the number of patients and was performed in only one institution. Conclusions Dermoscopy allowed a more precise prediction of SLN status. If a combined SCOREBRESEX was used to select patients for SLNB, 41.5% of procedures might be avoided.

引用

页码：1269 / 1277

页数：9