Evaluation of superoxide dismutase from Helicobacter pylori as a protective vaccine antigen

被引：18

作者：

Every, Alison L. ^{[1
]}

Stent, Andrew ^{[1
]}

Moloney, Margaret B. ^{[2
]}

Ng, Garrett Z. ^{[1
]}

Skene, Caroline D. ^{[1
]}

Edwards, Stirling J. ^{[2
]}

Sutton, Philip ^{[1
]}

机构：

[1] Univ Melbourne, Sch Vet Sci, Ctr Anim Biotechnol, Parkville, Vic 3010, Australia

[2] CSL Ltd, Res & Dev, Melbourne, Vic 3052, Australia

来源：

VACCINE | 2011年 / 29卷 / 07期

基金：

澳大利亚研究理事会;

关键词：

Helicobacter pylori; Vaccine antigen; Superoxide dismutase; MOUSE MODEL; IMMUNIZATION; INFECTION; CATALASE; MICE; COLONIZATION; RELEASE;

D O I：

10.1016/j.vaccine.2010.12.019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Helicobacter pylori, the major cause of gastric cancer, have mechanisms that allow colonization of the inhospitable gastric mucosa, including enzymes such as superoxide dismutase (SOD) which protect against reactive oxygen species. As SOD is essential for in vivo colonization, we theorized it might constitute a viable vaccine target. H. pylori SOD was expressed in E. coli and a purified recombinant protein used to vaccinate mice, prior to live H. pylori challenge. Partial protective immunity was induced, similar to that commonly observed with other antigens tested previously. This suggests SOD may have utility in a combination vaccine comprising several protective antigens. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1514 / 1518

页数：5

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