Common adverse events associated with the use of ribavirin for severe acute respiratory syndrome in Canada

被引：90

作者：

Knowles, SR

Phillips, EJ

Dresser, L

Matukas, L

机构：

[1] Sunnybrook & Womens Coll Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[2] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada

[3] Univ Toronto, Toronto, ON, Canada

来源：

CLINICAL INFECTIOUS DISEASES | 2003年 / 37卷 / 08期

关键词：

D O I：

10.1086/378304

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although information on efficacy and adverse drug reactions is lacking, ribavirin has been used empirically for the treatment of severe acute respiratory syndrome (SARS). We report common adverse events in 110 patients with suspected or probable SARS who were treated with ribavirin. Sixty-one percent of the patients had evidence of hemolytic anemia, and hypocalcemia and hypomagnesmia were reported in 58% and 46% of patients, respectively.

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页码：1139 / 1142

页数：4

相关论文

共 20 条

[1] Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area [J].

Booth, CM ;

Matukas, LM ;

Tomlinson, GA ;

Rachlis, AR ;

Rose, DB ;

Dwosh, HA ;

Walmsley, SL ;

Mazzulli, T ;

Avendano, M ;

Derkach, P ;

Ephtimios, IE ;

Kitai, I ;

Mederski, BD ;

Shadowitz, SB ;

Gold, WL ;

Hawryluck, LA ;

Rea, E ;

Chenkin, JS ;

Cescon, DW ;

Poutanen, SM ;

Detsky, AS .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (21) :2801-2809

[2] Meta-analysis: ribavirin-induced haemolytic anaemia in patients with chronic hepatitis C [J].

Chang, CH ;

Chen, KY ;

Lai, MY ;

Chan, KA .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2002, 16 (09) :1623-1632

[3] Adverse effects and other safety aspects of the hepatitis C antivirals [J].

Chutaputti, A .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2000, 15 :E156-E163

[4] Treatment of RSV pneumonia in adults - Evidence of ribavirin effectiveness? [J].

Dominguez, KD ;

Mercier, RC .

ANNALS OF PHARMACOTHERAPY, 1999, 33 (06) :739-741

[5] SEVERE MEASLES PNEUMONITIS IN ADULTS - EVALUATION OF CLINICAL CHARACTERISTICS AND THERAPY WITH INTRAVENOUS RIBAVIRIN [J].

FORNI, AL ;

SCHLUGER, NW ;

ROBERTS, RB .

CLINICAL INFECTIOUS DISEASES, 1994, 19 (03) :454-462

[6]

Glue P, 1999, SEMIN LIVER DIS, V19, P17

[7]

HALL CB, 1993, PEDIATRICS, V92, P501

[8]

Health Canada, 2003, SEV AC RESP SYNDR SA

[9]

*HLTH CAN ONL, 2003, UPD 43 SEV AC RESP S

[10] PROSPECTIVE, DOUBLE-BLIND, CONCURRENT, PLACEBO-CONTROLLED CLINICAL-TRIAL OF INTRAVENOUS RIBAVIRIN THERAPY OF HEMORRHAGIC-FEVER WITH RENAL SYNDROME [J].

HUGGINS, JW ;

HSIANG, CM ;

COSGRIFF, TM ;

GUANG, MY ;

SMITH, JI ;

WU, ZO ;

LEDUC, JW ;

ZHENG, ZM ;

MEEGAN, JM ;

WANG, QN ;

OLAND, DD ;

GUI, XE ;

GIBBS, PH ;

YUAN, GH ;

ZHANG, TM .

JOURNAL OF INFECTIOUS DISEASES, 1991, 164 (06) :1119-1127