Ruthenium-catalysed synthesis of tertiary amines from alcohols

被引：99
作者：
Haniti, M. [1 ]
Hamid, S. A. [1 ]
Williams, Jonathan M. J. [1 ]
机构：
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 47期
关键词：
D O I：
10.1016/j.tetlet.2007.09.134
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Secondary amines have been converted into tertiary amines by reactions with primary alcohols. A catalytic system of [Ru(cymene)Cl-2](2) with dppf has been shown to be effective for this transformation for a range of primary alcohols and secondary amines. The methodology has been applied to the one pot synthesis of Piribedil and other piperazine and morpholine-containing products. (C) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：8263 / 8265
页数：3
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