Concise Total Synthesis of Calothrixins A and B

被引：60

作者：

Abe, Takumi ^{[1
]}

Ikeda, Toshiaki ^{[1
]}

Yanada, Reiko ^{[2
]}

Ishikura, Minoru ^{[1
]}

机构：

[1] Hlth Sci Univ Hokkaido, Fac Pharmaceut Sci, Ishikari, Hokkaido 0610293, Japan

[2] Hiroshima Int Univ, Fac Pharmaceut Sci, Hiroshima 7370112, Japan

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 13期

关键词：

CROSS-COUPLING REACTION; INTRAMOLECULAR 2+2 PHOTOCYCLOADDITION; BIOMIMETIC SYNTHESIS; CONVENIENT METHOD; ROUTE; CYCLOADDITIONS; CATALYSIS; ALKENES;

D O I：

10.1021/ol201107a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The concise total synthesis of calothrixins A and B has been accomplished by utilizing the one-pot formation of hexatriene as a key intermediate via the palladium-catalyzed tandem cyclization/cross-coupling reaction of triethyl(indo1-2-yl)borate. In another key transformation, the indolo[3,2-j]phenanthridine core was prepared in high yield via Cu(I)-mediated 6 pi-electrocyclization.

引用

页码：3356 / 3359

页数：4

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