The Role of Human Dendritic Cells in HIV-1 Infection

被引：38
作者：
Ahmed, Zahra [1 ]
Kawamura, Tatsuyoshi [2 ]
Shimada, Shinji [2 ]
Piguet, Vincent [1 ]
机构：
[1] Cardiff Univ, Dept Dermatol, Inst Infect & Immun, Sch Med,Univ Hosp Wales, Cardiff CF14 4XN, S Glam, Wales
[2] Univ Yamanashi, Fac Med, Dept Dermatol, Yamanashi, Japan
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2015年 / 135卷 / 05期
基金：
英国惠康基金;
关键词：
IMMUNODEFICIENCY-VIRUS TYPE-1; CD4(+) T-CELLS; CYCLIC GMP-AMP; INNATE IMMUNE RECOGNITION; HUMAN LANGERHANS CELLS; EX-VIVO INFECTION; DC-SIGN; ENVELOPE GLYCOPROTEINS; LECTIN RECEPTORS; TRANS-INFECTION;
D O I：
10.1038/jid.2014.490
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC subsets, limiting or facilitating HIV transmission to CD4(+) T cells, respectively. LCs/DCs are also exposed to encountering HIV-1 and other sexually transmitted infections (herpes simplex virus-2, bacteria, fungi), which reprogram HIV-1 interaction with these cells. This review will summarize advances in the role of DCs during HIV-1 infection and discuss their potential involvement in the development of preventive strategies against HIV-1 and other sexually transmitted infections.
引用
收藏
页码：1225 / 1233
页数：9
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