Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex

被引：103

作者：

Kuhn, Marion ^{[1
]}

Wolf, Elias ^{[1
]}

Maier, Jonathan G. ^{[1
]}

Mainberger, Florian ^{[1
]}

Feige, Bernd ^{[1
]}

Schmid, Hanna ^{[1
]}

Buerklin, Jan ^{[1
]}

Maywald, Sarah ^{[1
]}

Mall, Volker ^{[2
]}

Jung, Nikolai H. ^{[2
]}

Reis, Janine ^{[3
]}

Spiegelhalder, Kai ^{[1
]}

Kloeppel, Stefan ^{[1
,3
]}

Sterr, Annette ^{[4
]}

Eckert, Anne ^{[5
]}

Riemann, Dieter ^{[1
]}

Normann, Claus ^{[1
]}

Nissen, Christoph ^{[1
]}

机构：

[1] Univ Med Ctr Freiburg, Dept Psychiat & Psychotherapy, Hauptstr 5, D-79104 Freiburg, Germany

[2] Tech Univ Munich, Dept Pediat, Arcisstr 21, D-80333 Munich, Germany

[3] Univ Med Ctr Freiburg, Dept Neurol, Breisacher Str 64, D-79106 Freiburg, Germany

[4] Univ Surrey, Dept Psychol, Guildford GU2 7XH, Surrey, England

[5] Transfac Res Platform Univ Basel, Neurobiol Lab Brain Aging & Mental Hlth, Psychiat Univ Clin Basel, Wilhelm Klein Str 27, CH-4012 Basel, Switzerland

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

关键词：

LONG-TERM DEPRESSION; HUMAN MOTOR CORTEX; CORTICAL EXCITABILITY; THETA ACTIVITY; WAKING EEG; DEPRIVATION; MEMORY; POTENTIATION; STIMULATION; HIPPOCAMPUS;

D O I：

10.1038/ncomms12455

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sleep is ubiquitous in animals and humans, but its function remains to be further determined. The synaptic homeostasis hypothesis of sleep-wake regulation proposes a homeostatic increase in net synaptic strength and cortical excitability along with decreased inducibility of associative synaptic long-term potentiation (LTP) due to saturation after sleep deprivation. Here we use electrophysiological, behavioural and molecular indices to non-invasively study net synaptic strength and LTP-like plasticity in humans after sleep and sleep deprivation. We demonstrate indices of increased net synaptic strength (TMS intensity to elicit a predefined amplitude of motor-evoked potential and EEG theta activity) and decreased LTP-like plasticity (paired associative stimulation induced change in motor-evoked potential and memory formation) after sleep deprivation. Changes in plasma BDNF are identified as a potential mechanism. Our study indicates that sleep recalibrates homeostatic and associative synaptic plasticity, believed to be the neural basis for adaptive behaviour, in humans.

引用

页数：9

共 52 条

[51] A deficit in the ability to form new human memories without sleep [J].

Yoo, Seung-Schik ;

Hu, Peter T. ;

Gujar, Ninad ;

Jolesz, Ferenc A. ;

Walker, Matthew P. .

NATURE NEUROSCIENCE, 2007, 10 (03) :385-392

[52]

Ziemann Ulf, 2004, Suppl Clin Neurophysiol, V57, P702

← 1 2 3 4 5 6 →