Cascade Michael-Aldol reaction: efficient annulation of sulfonamide chalcones into novel cyclohexenones under solvent-free conditions

被引：7

作者：

Agrawal, Nikita R. ^{[1
]}

Bahekar, Sandeep P. ^{[1
]}

Agrawal, Abhijeet R. ^{[2
]}

Sarode, Prashant B. ^{[1
]}

Chandak, Hemant S. ^{[1
]}

机构：

[1] GS Sci Arts & Commerce Coll, Dept Chem, Khamgaon 444303, India

[2] IISER Kolkata, Dept Chem Sci, Mohanpur 741246, India

来源：

ARKIVOC | 2016年

关键词：

Cascade Michael-Aldol reaction; solvent-free synthesis; sulfonamide cyclohexenones; sulfonamide chalcones; CATALYZED N-ARYLATION; ORGANIC-SYNTHESIS; ACID; DERIVATIVES; INHIBITORS; PHEROMONE; PRODUCTS; FACILE; LIQUID; ESTERS;

D O I：

10.3998/ark.5550190.p009.488

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, convenient and efficient synthesis of novel sulfonamide cyclohexenones from differently substituted sulfonamide chalcones has been developed. Syntheses of cyclohexenones have been achieved via cascade Michael-Aldol reaction under solvent free condition. This process features mild and solvent-free synthesis of the titled compounds with high yields (18 examples, up to 95% yield). The synthesized scaffold is a promising intermediate for the further transformation into various heterocyclic compounds.

引用

页码：227 / 245

页数：19

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