Mechanism of exercise-induced analgesia: what we can learn from physically active animals

被引：55
作者：
Lesnak, Joseph B. [1 ]
Sluka, Kathleen A. [1 ]
机构：
[1] Univ Iowa, Dept Phys Therapy & Rehabil Sci, Iowa City, IA USA
来源：
PAIN REPORTS | 2020年 / 5卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Pain; Exercise; Hyperalgesia; Analgesia; Animal models; Central mechanisms; Peripheral mechanisms; ATTENUATES NEUROPATHIC PAIN; LOW-INTENSITY EXERCISE; CLINICAL-PRACTICE GUIDELINES; CHRONIC CONSTRICTION INJURY; MORPHINE-INDUCED ANALGESIA; NUCLEUS RAPHE MAGNUS; WATER SWIM ANALGESIA; SPINAL-CORD; TREADMILL EXERCISE; PERIAQUEDUCTAL GRAY;
D O I：
10.1097/PR9.0000000000000850
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Physical activity has become a first-line treatment in rehabilitation settings for individuals with chronic pain. However, research has only recently begun to elucidate the mechanisms of exercise-induced analgesia. Through the study of animal models, exercise has been shown to induce changes in the brain, spinal cord, immune system, and at the site of injury to prevent and reduce pain. Animal models have also explored beneficial effects of exercise through different modes of exercise including running, swimming, and resistance training. This review will discuss the central and peripheral mechanisms of exercise-induced analgesia through different modes, intensity, and duration of exercise as well as clinical applications of exercise with suggestions for future research directions.
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页数：16
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