Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparum

被引：53

作者：

Isozumi, Rie ^{[1
]}

Uemura, Haruki ^{[2
]}

Kimata, Isao ^{[1
]}

Ichinose, Yoshio ^{[2
]}

Logedi, John ^{[3
]}

Omar, Ahmeddin H. ^{[3
]}

Kaneko, Akira ^{[1
,4
]}

机构：

[1] Osaka City Univ, Osaka 558, Japan

[2] Nagasaki Univ, Inst Trop Med, Nagasaki 852, Japan

[3] Minist Publ Hlth & Sanitat, Nairobi, Kenya

[4] Karolinska Inst, Stockholm, Sweden

来源：

EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 03期

关键词：

MALARIA;

D O I：

10.3201/eid2103.140898

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We looked for mutations in the Plasmodium falciparum K13 propeller gene of an artemisinin-resistant parasite on islands in Lake Victoria, Kenya, where transmission in 2012-2013 was high. The 4 new types of nonsynonymous, and 5 of synonymous, mutations we detected among 539 samples analyzed provide clues to understanding artemisinin-resistant parasites.

引用

页码：490 / 492

页数：3

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