Galectin-3 gene (LGALS3) expression in experimental atherosclerosis and cultured smooth muscle cells

被引：70

作者：

Arar, C

Gaudin, JC

Capron, L

Legrand, A

机构：

[1] CNRS, Ctr Biophys Mol, F-45071 Orleans 2, France

[2] Univ Orleans, F-45071 Orleans, France

[3] Hotel Dieu, Serv Med Interne, F-75181 Paris 04, France

来源：

FEBS LETTERS | 1998年 / 430卷 / 03期

关键词：

soluble galactose binding lectin; experimental atherosclerosis; reverse transcription polymerase chain reaction; promoter; transfection; DNA methylation;

D O I：

10.1016/S0014-5793(98)00683-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The galectin-3 gene (LGALS3) encodes a beta-galactose binding lectin. LGALS3 expression is associated with neoplastic transformation and,vith differentiation of monocytes to macrophages. Factors involved in migration, proliferation, adhesion and differentiation of vascular smooth muscle cells (SMC) play a major role during atherosclerosis development, Expression of the galectin-3 gene was not detected in quiescent SMC but was activated in aortas of hypercholesterolemic rabbits, in aortas of rats after balloon injury and in cultured SMC. These results suggest that galectin-3 production is involved in the developmental process of atherogenesis. (C) 1998 Federation of European Biochemical Societies.

引用

页码：307 / 311

页数：5

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