A theoretical molecular network for dyslexia: integrating available genetic findings

被引：89
作者：
Poelmans, G. [2 ]
Buitelaar, J. K. [2 ]
Pauls, D. L. [3 ]
Franke, B. [1 ,4 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, NL-6500 HB Nijmegen, Netherlands
[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Human Genet Res,Psychiat & Neurodev Genet Uni, Boston, MA USA
[4] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Psychiat, NL-6500 HB Nijmegen, Netherlands
来源：
MOLECULAR PSYCHIATRY | 2011年 / 16卷 / 04期
关键词：
dyslexia; genetics; neurodevelopment; molecular network; bioinformatics; QUANTITATIVE-TRAIT LOCUS; END-PRODUCTS RAGE; ACTIVATED PROTEIN-KINASE; FAMILY-BASED ASSOCIATION; LONG-TERM POTENTIATION; FRAGILE-X-SYNDROME; READING-DISABILITY; SUSCEPTIBILITY LOCUS; DEVELOPMENTAL DYSLEXIA; NEURONAL MIGRATION;
D O I：
10.1038/mp.2010.105
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Developmental dyslexia is a common specific childhood learning disorder with a strong heritable component. Previous studies using different genetic approaches have identified several genetic loci and candidate genes for dyslexia. In this article, we have integrated the current knowledge on 14 dyslexia candidate genes suggested by cytogenetic findings, linkage and association studies. We found that 10 of the 14 dyslexia candidate genes (ROBO1, KIAA0319, KIAA0319L, S100B, DOCK4, FMR1, DIP2A, GTF2I, DYX1C1 and DCDC2) fit into a theoretical molecular network involved in neuronal migration and neurite outgrowth. Based on this, we also propose three novel dyslexia candidate genes (SLIT2, HMGB1 and VAPA) from known linkage regions, and we discuss the possible involvement of genes emerging from the two reported genome-wide association studies for reading impairment-related phenotypes in the identified network. Molecular Psychiatry (2011) 16, 365-382; doi:10.1038/mp.2010.105; published online 19 October 2010
引用
收藏
页码：365 / 382
页数：18
相关论文
共 155 条
[31]   The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo [J].
Davis, S ;
Vanhoutte, P ;
Pagés, C ;
Caboche, J ;
Laroche, S .
JOURNAL OF NEUROSCIENCE, 2000, 20 (12) :4563-4572
[32]   Confirmation of dyslexia susceptibility loci on chromosomes 1p and 2p, but not 6p in a dutch sib-pair collection [J].
de Kovel, Carolien G. F. ;
Franke, Barbara ;
Hol, Frans A. ;
Lebrec, Jeremie J. P. ;
Maassen, Ben ;
Brunner, Han ;
Padberg, George W. ;
Platko, Jill ;
Pauls, David .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2008, 147B (03) :294-300
[33]   Genomewide scan identifies susceptibility locus for dyslexia on Xq27 in an extended Dutch family [J].
de Kovel, CGF ;
Hol, FA ;
Heister, JGAM ;
Willemen, JJHT ;
Sandkuijl, LA ;
Franke, B ;
Padberg, GW .
JOURNAL OF MEDICAL GENETICS, 2004, 41 (09) :652-657
[34]   Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses [J].
Deffenbacher, KE ;
Kenyon, JB ;
Hoover, DM ;
Olson, RK ;
Pennington, BF ;
DeFries, JC ;
Smith, SD .
HUMAN GENETICS, 2004, 115 (02) :128-138
[35]   A Common Variant Associated with Dyslexia Reduces Expression of the KIAA0319 Gene [J].
Dennis, Megan Y. ;
Paracchini, Silvia ;
Scerri, Thomas S. ;
Prokunina-Olsson, Ludmila ;
Knight, Julian C. ;
Wade-Martins, Richard ;
Coggill, Penny ;
Beck, Stephan ;
Green, Eric D. ;
Monaco, Anthony P. .
PLOS GENETICS, 2009, 5 (03)
[36]   A novel NF-κB-inducing kinase-MAPK signaling pathway up-regulates NF-κB activity in melanoma cells [J].
Dhawan, P ;
Richmond, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (10) :7920-7928
[37]   Molecular mechanisms controlling midline crossing by precerebellar neurons [J].
Di Meglio, Thomas ;
Nguyen-Ba-Charvet, Kim T. ;
Tessier-Lavigne, Marc ;
Sotelo, Constantino ;
Chedotal, Alain .
JOURNAL OF NEUROSCIENCE, 2008, 28 (25) :6285-6294
[38]  
Fagerheim T, 1999, J MED GENET, V36, P664
[39]   Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth [J].
Fard, Shahrzad Shirazi ;
Kele, Julianna ;
Vilar, Marcal ;
Paratcha, Gustavo ;
Ledda, Fernanda .
PLOS ONE, 2010, 5 (03)
[40]   Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia [J].
Fisher, SE ;
Francks, C ;
Marlow, AJ ;
MacPhie, IL ;
Newbury, DF ;
Cardon, LR ;
Ishikawa-Brush, Y ;
Richardson, AJ ;
Talcott, JB ;
Gayán, J ;
Olson, RK ;
Pennington, BF ;
Smith, SD ;
DeFries, JC ;
Stein, JF ;
Monaco, AP .
NATURE GENETICS, 2002, 30 (01) :86-91
12345678910