A theoretical molecular network for dyslexia: integrating available genetic findings

被引：89
作者：
Poelmans, G. [2 ]
Buitelaar, J. K. [2 ]
Pauls, D. L. [3 ]
Franke, B. [1 ,4 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, NL-6500 HB Nijmegen, Netherlands
[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Human Genet Res,Psychiat & Neurodev Genet Uni, Boston, MA USA
[4] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Psychiat, NL-6500 HB Nijmegen, Netherlands
来源：
MOLECULAR PSYCHIATRY | 2011年 / 16卷 / 04期
关键词：
dyslexia; genetics; neurodevelopment; molecular network; bioinformatics; QUANTITATIVE-TRAIT LOCUS; END-PRODUCTS RAGE; ACTIVATED PROTEIN-KINASE; FAMILY-BASED ASSOCIATION; LONG-TERM POTENTIATION; FRAGILE-X-SYNDROME; READING-DISABILITY; SUSCEPTIBILITY LOCUS; DEVELOPMENTAL DYSLEXIA; NEURONAL MIGRATION;
D O I：
10.1038/mp.2010.105
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Developmental dyslexia is a common specific childhood learning disorder with a strong heritable component. Previous studies using different genetic approaches have identified several genetic loci and candidate genes for dyslexia. In this article, we have integrated the current knowledge on 14 dyslexia candidate genes suggested by cytogenetic findings, linkage and association studies. We found that 10 of the 14 dyslexia candidate genes (ROBO1, KIAA0319, KIAA0319L, S100B, DOCK4, FMR1, DIP2A, GTF2I, DYX1C1 and DCDC2) fit into a theoretical molecular network involved in neuronal migration and neurite outgrowth. Based on this, we also propose three novel dyslexia candidate genes (SLIT2, HMGB1 and VAPA) from known linkage regions, and we discuss the possible involvement of genes emerging from the two reported genome-wide association studies for reading impairment-related phenotypes in the identified network. Molecular Psychiatry (2011) 16, 365-382; doi:10.1038/mp.2010.105; published online 19 October 2010
引用
收藏
页码：365 / 382
页数：18
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