ICE/CED-3 proteases in apoptosis

被引：134
作者：
Whyte, M
机构：
来源：
TRENDS IN CELL BIOLOGY | 1996年 / 6卷 / 07期
关键词：
D O I：
10.1016/0962-8924(96)20025-X
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
An expanding family of cysteine proteases, of which interleukin-1 beta-converting enzyme (ICE) is the prototype, has been shown to play a key role in mammalian cell apoptosis. ICE is both a structural and functional homologue of the nematode 'death gene' ced-3. Here, Moira Whyte discusses how functional characterization of these ICE-like proteases and identification of their substrates is helping to elucidate the biochemical processes underlying the stereotyped morphology of apoptosis and to identify potential targets for therapy.
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页码：245 / 248
页数：4
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