Molecular characterization of acute myeloid leukemia and its impact on treatment

被引：17

作者：

Frankfurt, Olga ^{[1
]}

Licht, Jonathan D. ^{[1
]}

Tallman, Martin S. ^{[1
]}

机构：

[1] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Div Hematol & Oncol, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

CURRENT OPINION IN ONCOLOGY | 2007年 / 19卷 / 06期

关键词：

acute myeloid leukemia; acute promyelocytic leukemia; core-binding factor leukemia; cytogenetically normal acute; myeloid leukemia; cytogenetics; molecular analysis;

D O I：

10.1097/CCO.0b013e3282f10e55

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose of review Molecular aberrations are playing an ever increasing role in guiding classification, prognosis, and therapeutic strategies in patients with acute myeloid leukemia. This review outlines recent strides in our understanding of the molecular characteristics of acute myeloid leukemia. Recent findings We highlight the novel concept of preferential co-expression of certain mutations, summarize recent data on the clinically relevant prognostic role of known and novel molecular aberrations, and emphasize the emerging role of gene expression profiling and minimal residual disease monitoring. Summary We review the molecular heterogeneity within already established categories of acute myeloid leukemia and discuss how these data may translate into prognostic, molecular-based therapy stratification to improve patient outcome.

引用

页码：635 / 649

页数：15

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