Regulation of GATA-3 Expression during CD4 Lineage Differentiation

被引：21

作者：

Gimferrer, Idoia ^{[1
]}

Hu, Taishan ^{[1
]}

Simmons, Amie ^{[1
]}

Wang, Chi ^{[2
]}

Souabni, Abdallah ^{[3
]}

Busslinger, Meinrad ^{[3
]}

Bender, Timothy P. ^{[4
]}

Hernandez-Hoyos, Gabriela ^{[2
]}

Alberola-Ila, Jose ^{[1
,5
]}

机构：

[1] Oklahoma Med Res Fdn, Immunobiol & Canc Res Program, Oklahoma City, OK 73104 USA

[2] CALTECH, Div Biol, Pasadena, CA 91001 USA

[3] Res Inst Mol Pathol, A-1030 Vienna, Austria

[4] Univ Virginia, Dept Microbiol, Charlottesville, VA 22908 USA

[5] Univ Oklahoma, Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK 73104 USA

来源：

JOURNAL OF IMMUNOLOGY | 2011年 / 186卷 / 07期

基金：

美国国家卫生研究院;

关键词：

T-CELL DEVELOPMENT; TRANSCRIPTION FACTOR GATA-3; CYTOKINE GENE-EXPRESSION; C-MYB; THYMOCYTE DEVELOPMENT; SELECTION; COMMITMENT; THPOK; INDUCTION; MOUSE;

D O I：

10.4049/jimmunol.1003505

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

GATA-3 is necessary for the development of MHC class II-restricted CD4 T cells, and its expression is increased during positive selection of these cells. TCR signals drive this upregulation, but the signaling pathways that control this process are not well understood. Using genetic and pharmacological approaches, we show that GATA-3 upregulation during thymocyte-positive selection is the result of additive inputs from the Ras/MAPK and calcineurin pathways. This upregulation requires the presence of the transcription factor c-Myb. Furthermore, we show that TH-POK can also upregulate GATA-3 in double-positive thymocytes, suggesting the existence of a positive feedback loop that contributes to lock in the initial commitment to the CD4 lineage during differentiation. The Journal of Immunology, 2011, 186: 3892-3898.

引用

页码：3892 / 3898

页数：7

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