SERUM MONOCYTE CHEMOKINE PROTEIN-1 LEVELS BEFORE AND AFTER PARATHYROIDECTOMY IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM

被引：14
作者：
Patel, Hemal [1 ]
Trooskin, Stanley [2 ,3 ]
Shapses, Sue [4 ]
Sun, Wei [1 ]
Wang, Xiangbing [1 ]
机构：
[1] Rutgers Robert Wood Johnson Med Sch, Dept Med, Div Endocrinol, New Brunswick, NJ 08903 USA
[2] Rutgers Robert Wood Johnson Med Sch, Dept Med, Div Gen Surg, New Brunswick, NJ 08903 USA
[3] Rutgers Robert Wood Johnson Med Sch, Dept Surg, New Brunswick, NJ 08903 USA
[4] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08903 USA
来源：
ENDOCRINE PRACTICE | 2014年 / 20卷 / 11期
关键词：
CARDIOVASCULAR RISK-FACTORS; CHEMOATTRACTANT PROTEIN-1; OBESE SUBJECTS; MACROPHAGE INFILTRATION; INSULIN-RESISTANCE; ADIPOSE-TISSUE; WEIGHT-LOSS; MCP-1; HORMONE; EXPRESSION;
D O I：
10.4158/EP14104.OR
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To investigate the effects of parathyroidectomy on serum monocyte chemokine protein-1 (MCP-1) levels in patients with primary hyperparathyroidism (PHPT). Methods: Forty-three PHPT patients, age 56 +/- 12 years, underwent minimally invasive parathyroidectomy. Serum samples were collected at 0 and 15 to 20 minutes after parathyroid adenoma removal. Serum samples were stored at -70 degrees C until time of assay. Results: In 40 PHPT patients with a single adenoma, MCP-1 levels decreased from 342 +/- 103 to 250 +/- 77 pg/mL (P<.001) 15 to 20 minutes after parathyroid adenoma removal. MCP-1 levels were positively correlated with intact parathyroid hormone (PTH) levels (R = 0.47; P<.01). In 3 PHPT patients with double parathyroid adenoma, MCP-1 levels did not decrease after removal of the first adenoma but decreased 15 to 20 minutes after second adenoma removal. Conclusion: Our results provide evidence that the decrease in serum intact PTH due to minimally invasive parathyroidectomy results in an immediate decrease in serum MCP-1 levels.
引用
收藏
页码：1165 / 1169
页数：5
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