An Efficient and Rapid Synthesis of 1H-Pyrazolo[3, 4-d]-pyrimidin-4(5H)-one in Water

被引：1

作者：

Su, Ziqi ^{[1
]}

Zhang, Qi ^{[1
]}

Zhao, Jieqiang ^{[1
]}

Zhao, Tao ^{[1
]}

Liu, Wenyi ^{[1
]}

Wang, Huiping ^{[2
]}

Xu, Juan ^{[2
]}

Li, Jiarong ^{[1
]}

机构：

[1] Beijing Inst Technol, Sch Chem & Chem Engn, Beijing 102488, Peoples R China

[2] Natl Res Inst Family Planning, Beijing 100081, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 41卷 / 09期

关键词：

one pot conversion; pyrazolo[3,4-d]pyrimidin-4(5H)-one; sodium hydroxide; green solvent; water; BIOLOGICAL EVALUATION; DERIVATIVES; SILDENAFIL; INHIBITORS; ALLOPURINOL; ANTICANCER;

D O I：

10.6023/cjoc202104043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrazolopyrimidinone compounds have many biological activities and been widely used due to the similar structure of purines in organisms. However, the traditional synthetic methods suffered from several drawbacks, such as acylation and cyclization. Herein, one pot cyclization of 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one was developed by one pot conversion of 5-amino-4-cyano-pyrazole and aromatic aldehydes in the presence of sodium hydroxide using water as media. The reaction was carried out under the conditions of easily available raw materials, simple operation, and showed good tolerance to various functional groups.

引用

页码：3701 / 3709

页数：9

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