Three new peroxides from the sponge Plakinastrella species

被引:41
作者
Chen, Y
Killday, KB
McCarthy, PJ
Schimoler, R
Chilson, K
Selitrennikoff, C
Pomponi, SA
Wright, AE
机构
[1] Harbor Branch Oceanog Inst Inc, Div Biomed Marine Res, Ft Pierce, FL 34946 USA
[2] Mycol Inc, Denver, CO 80262 USA
来源
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 02期
关键词
D O I
10.1021/np000368+
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Two new five-membered-ring peroxide acids, plakinic acid F (3) and epiplakinic acid F (4), and a new peroxide-lactone, plakortolide F (5), were isolated from a sponge of the genus Plakinastrella collected from Felicite Island, Seychelles. The structures were elucidated through spectral analysis. The free acids 3 and 4 exhibit moderate antifungal activity against Candida albicans with minimum inhibitory concentrations of 25 mug/mL (SDB) and 3.1 mug/mL (RPMI) for 3, and 25 mug/mL (SDB) and 6.25 mug/mL (RPMI) for 4, respectively. Both also showed moderate in vitro inhibition of Aspergillus fumigatus with IC90's of 25 mug/mL.
引用
收藏
页码:262 / 264
页数:3
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