Satoshi Omura: in pursuit of nature's bounty

被引：15

作者：

Crump, A ^{[1
]}

Otoguro, K ^{[1
]}

机构：

[1] Kitasato Inst, Res Ctr Trop Dis, Minato Ku, Tokyo 1088642, Japan

来源：

TRENDS IN PARASITOLOGY | 2005年 / 21卷 / 03期

关键词：

D O I：

10.1016/j.pt.2005.01.005

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Professor Satoshi Omura has spent over 40 years searching for bioactive compounds in naturally occurring microorganisms, discovering more than 330 biomedically and commercially significant compounds in the process. The discovery, development and delivery of the drug ivermectin has pioneered the way for subsequent partnerships between the public and private sectors, as well as international collaborations and drug donation programmes. It has involved a variety of ground-breaking steps, providing a curative drug that will help rid Africa and the world of at least one of the most devastating of all human diseases, onchocerciasis. It has also improved the health of pets and livestock around the globe, and encouraged development of a community-based delivery mechanism that could herald a revolution in public health care in Africa.

引用

页码：126 / 132

页数：7

共 26 条

[1] Macrofilaricides and onchocerciasis control, mathematical modelling of the prospects for elimination [J].

Alley, WS ;

van Oortmarssen, GGJ ;

Boatin, BBA ;

Nagelkerke, NNJD ;

Plaisier, AAP ;

Remme, HJ ;

Lazdins, J ;

Borsboom, GJJM ;

Habbema, JDF .

BMC PUBLIC HEALTH, 2001, 1 (1) :1-5

[2]

[Anonymous], 2002, MACROLIDE ANTIBIOTIC, DOI DOI 10.1016/B978-012526451-8/50014-X

[3]

AZIZ MA, 1982, LANCET, V2, P171

[4]

AZIZ MA, 1982, LANCET, V2, P1456

[5] AVERMECTINS, NEW FAMILY OF POTENT ANTHELMINTIC AGENTS - PRODUCING ORGANISM AND FERMENTATION [J].

BURG, RW ;

MILLER, BM ;

BAKER, EE ;

BIRNBAUM, J ;

CURRIE, SA ;

HARTMAN, R ;

KONG, YL ;

MONAGHAN, RL ;

OLSON, G ;

PUTTER, I ;

TUNAC, JB ;

WALLICK, H ;

STAPLEY, EO ;

OIWA, R ;

OMURA, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 15 (03) :361-367

[6] IVERMECTIN - A POTENT NEW ANTI-PARASITIC AGENT [J].

CAMPBELL, WC ;

FISHER, MH ;

STAPLEY, EO ;

ALBERSSCHONBERG, G ;

JACOB, TA .

SCIENCE, 1983, 221 (4613) :823-828

[7]

Dadzie Yankum, 2003, Filaria J, V2, P2, DOI 10.1186/1475-2883-2-2

[8] AVERMECTINS, NEW FAMILY OF POTENT ANTHELMINTIC AGENTS - EFFICACY OF THE B1A COMPONENT [J].

EGERTON, JR ;

OSTLIND, DA ;

BLAIR, LS ;

EARY, CH ;

SUHAYDA, D ;

CIFELLI, S ;

RIEK, RF ;

CAMPBELL, WC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 15 (03) :372-378

[9] STUDIES ON PENICILLINASE INHIBITORS PRODUCED BY MICROORGANISMS [J].

HATA, T ;

OHNO, H ;

OMURA, S ;

TAKESHIMA, H ;

YAMAGUCH.N ;

IWAI, Y .

JOURNAL OF ANTIBIOTICS, 1972, 25 (08) :473-+

[10] Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130 [J].

Hayashi, M ;

Rho, MC ;

Enomoto, A ;

Fukami, A ;

Kim, YP ;

Kikuchi, Y ;

Sunazuka, T ;

Hirose, T ;

Komiyama, K ;

Omura, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (23) :14728-14733

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