Trypanocidal Activity of Oxoaporphine and Pyrimidine-β-Carboline Alkaloids from the Branches of Annona foetida Mart. (Annonaceae)

被引：60

作者：

Costa, Emmanoel Vilaca ^{[2
]}

Belem Pinheiro, Maria Lucia ^{[1
]}

Leao de Souza, Afonso Duarte ^{[1
]}

Barison, Andersson ^{[3
]}

Campos, Francinete Ramos ^{[4
]}

Valdez, Rodrigo Hinojosa ^{[5
]}

Ueda-Nakamura, Tania ^{[5
]}

Dias Filho, Benedito Prado ^{[5
]}

Nakamura, Celso Vataru ^{[5
]}

机构：

[1] Univ Fed Amazonas, Dept Chem, BR-69077000 Manaus, AM, Brazil

[2] Univ Fed Sergipe, Dept Chem, LABORGAN, BR-49100000 Sao Cristovao, SE, Brazil

[3] Univ Fed Parana, Dept Chem, BR-81531990 Curitiba, PR, Brazil

[4] Univ Fed Parana, Dept Pharm, BR-81531990 Curitiba, PR, Brazil

[5] Univ Estadual Maringa, Dept Basic Hlth Sci, BR-87020900 Maringa, PR, Brazil

来源：

MOLECULES | 2011年 / 16卷 / 11期

关键词：

annonaceae; Annona foetida; alkaloids; oxoaporphine alkaloids; pyrimidine-beta-carboline alkaloids; trypanocidal activity; ANTILEISHMANIAL ACTIVITY; TRYPANOSOMA-CRUZI; METHOXYANNOMONTINE; DITERPENOIDS; CONSTITUENTS; ANNOMONTINE; MONTANA; LEAVES; STEM;

D O I：

10.3390/molecules16119714

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH(2)Cl(2) extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 2-4 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi.

引用

页码：9714 / 9720

页数：7

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