No significant association between the genetic polymorphisms in the GSK-3β gene and schizophrenia in the Chinese population

被引：14
|
作者：
Meng, Junwei [1 ,2 ]
Shi, Yongyong [1 ,2 ]
Zhao, Xinzhi [1 ,2 ]
Zhou, Jian [1 ,2 ]
Zheng, Yonglan [1 ]
Tang, Ruqi [1 ,2 ]
Ma, Gang [1 ,2 ]
Zhu, Xuming [1 ]
He, Zangdong [1 ,2 ]
Wang, Zhe [2 ]
Xu, Yifeng [3 ]
Feng, Guoyin [3 ]
He, Lin [1 ]
机构：
[1] Chinese Acad Sci, Inst Nutr Sci, SIBS, Shanghai 200031, Peoples R China
[2] Shanghai Jiao Tong Univ, BioX Ctr, Shanghai 200030, Peoples R China
[3] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China
来源：
JOURNAL OF PSYCHIATRIC RESEARCH | 2008年 / 42卷 / 05期
基金：
中国国家自然科学基金;
关键词：
schizophrenia; glycogen synthase kinase-3 beta (GSK-3 beta); SNP; case-control study; paranoid;
D O I：
10.1016/j.jpsychires.2007.01.005
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The GSK-3 beta gene encodes a protein kinase which is abundant in the brain, and its product is involved in signal transduction cascades of neuronal cell development, energy metabolism and body pattern formation. Previous studies have suggested that GSK-3 beta might act as a potential candidate locus for schizophrenia susceptibility. We genotyped six SNPs within the gene and conducted a case-control study involving 329 schizophrenic patients and 288 healthy subjects in the Chinese population. We examined allele and genotype frequencies and haplotype distributions in the subtype of paranoid schizophrenic patients as well as schizophrenic subjects in general. Our results fail to replicate the association of the GSK-3 beta gene with susceptibility to schizophrenia in the Chinese population. (C) 2007 Published by Elsevier Ltd.
引用
收藏
页码：365 / 370
页数：6
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