Canonical and Noncanonical Signaling Roles of β-Arrestins in Inflammation and Immunity

被引：4

作者：

Ahmadzai, Mohammad M. ^{[1
]}

Broadbent, David ^{[1
]}

Occhiuto, Christopher ^{[1
]}

Yang, Canchai ^{[1
]}

Das, Rupali ^{[1
]}

Subramanian, Hariharan ^{[1
]}

机构：

[1] Michigan State Univ, E Lansing, MI 48824 USA

来源：

G PROTEIN-COUPLED RECEPTORS IN IMMUNE RESPONSE AND REGULATION | 2017年 / 136卷

关键词：

PROTEINASE-ACTIVATED RECEPTOR-2; CLATHRIN-MEDIATED ENDOCYTOSIS; NUCLEAR EXPORT SIGNAL; NF-KAPPA-B; ADRENERGIC-RECEPTOR; CHEMOKINE RECEPTORS; BETA(2)-ADRENERGIC RECEPTOR; DEPENDENT ENDOCYTOSIS; RHEUMATOID-ARTHRITIS; COUPLED RECEPTORS;

D O I：

10.1016/bs.ai.2017.05.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

beta-Arrestins are a highly conserved family of cytosolic adaptor proteins that contribute to many immune functions by orchestrating the desensitization and internalization of cellsurface G protein-coupled receptors (GPCRs) via well-studied canonical interactions. In cells of the innate and adaptive immune system, beta-arrestins also subserve a parallel but less understood role in which they propagate, rather than terminate, intracellular signal transduction cascades. Because beta-arrestins are promiscuous in their binding, they are capable of interacting with several different GPCRs and downstream effectors; in doing so, they vastly expand the repertoire of cellular responses evoked by agonist binding and the scope of responses that may contribute to inflammation during infectious and sterile insults. In this chapter, we attempt to provide an overview of the canonical and noncanonical roles of beta-arrestins in inflammatory diseases.

引用

页码：279 / 313

页数：35

共 121 条

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