Strain-Promoted Cross-Linking of PEG-Based Hydrogels via Copper-Free Cycloaddition

被引：108

作者：

Zheng, Jukuan ^{[1
]}

Callahan, Laura A. Smith ^{[1
]}

Hao, Jinkun ^{[2
]}

Guo, Kai ^{[1
]}

Wesdemiotis, Chrys ^{[1
,3
]}

Weiss, R. A. ^{[2
]}

Becker, Matthew L. ^{[1
,4
]}

机构：

[1] Univ Akron, Dept Polymer Sci, Akron, OH 44325 USA

[2] Univ Akron, Dept Polymer Engn, Akron, OH 44325 USA

[3] Univ Akron, Dept Chem, Akron, OH 44325 USA

[4] Austen Bioinnovat Inst Akron, Ctr Biomat Med, Akron, OH 44308 USA

来源：

ACS MACRO LETTERS | 2012年 / 1卷 / 08期

基金：

美国国家科学基金会;

关键词：

CLICK CHEMISTRY; PEPTIDE; DESIGN; POLYMER;

D O I：

10.1021/mz3003775

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The synthesis of a 4-dibenzocyclooctyriol (DIBO) functionalized poly(ethylene glycol) (PEG) and fabrication of hydrogels via strain promoted, metal free, azide-alkyne cycloaddition is reported. The resulting hydrogel materials provide a versatile alternative to encapsulate cells that are sensitive to photochemical or chemical cross linking mechanisms.

引用

页码：1071 / 1073

页数：3