Vitamin D and cancer: antineoplastic effects of 1α,25(OH)2-vitamin D3

被引：0
作者：
Gonzalez Pardo, Veronica
Boland, Ricardo
Russo de Boland, Ana [1 ]
机构：
[1] Univ Nacl Sur, Dept Biol Bioquim & Farm, RA-8000 Bahia Blanca, Buenos Aires, Argentina
来源：
MEDICINA-BUENOS AIRES | 2012年 / 72卷 / 02期
关键词：
Vitamin D; cancer; antineoplastic mechanism; D-RECEPTOR VDR; PROTEIN-KINASE-C; 1,25-DIHYDROXYVITAMIN D-3; PROSTATE-CANCER; GENE-EXPRESSION; COLON-CANCER; D ANALOGS; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; MONOCYTIC DIFFERENTIATION; MAMMARY CARCINOGENESIS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Vitamin D and cancer: antineoplastic effects of 1 alpha,25(OH)(2)-vitamin D-3. The hormonal form of vitamin D, 1 alpha,25(OH)(2)-vitamin D-3 (1 alpha,25(OH)(2)D-3), in addition of playing a central role in the control of calcium homeostasis in the body, regulates the growth and differentiation of different cell types, including cancer cells. At present several epidemiologic and clinical studies investigate the effect of the hormone in these cells due to the interest in the therapeutic use of 1 alpha,25(OH)(2)D-3 and analogues with less calcemic activity for prevention or treatment of cancer. This review describes vitamin D endocrine system, its mechanism of action, its antineoplastic activity and provides information about the latest advances in the study of new hormone analogues with less calcemic activity for cancer treatment.
引用
收藏
页码：143 / 149
页数：7
相关论文
共 87 条
[1]   Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland) [J].
Ahonen, MH ;
Tenkanen, L ;
Teppo, L ;
Hakama, M ;
Tuohimaa, P .
CANCER CAUSES & CONTROL, 2000, 11 (09) :847-852
[2]   Co-expression of CYP27B1 enzyme with the 1.5 kb CYP27B1 promoter-luciferase transgene in the mouse [J].
Anderson, Paul H. ;
Hendrix, Ivanka ;
Sawyer, Rebecca K. ;
Zarrinkalam, Reza ;
Manavis, Jim ;
Sarvestani, Ghafar T. ;
May, Brian K. ;
Morris, Howard A. .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2008, 285 (1-2) :1-9
[3]   Selective inhibition of cyclooxygenase-2 (COX-2) by 1α,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog [J].
Aparna, Rachamallu ;
Subhashini, Jagu ;
Roy, Karnati R. ;
Reddy, G. Satyanarayana ;
Robinson, Matthew ;
Uskokovic, Milan R. ;
Reddy, Gorla Venkateswara ;
Reddanna, Pallu .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2008, 104 (05) :1832-1842
[4]   Vitamin D analogues increase p53, p21, and apoptosis in a xenograft model of human retinoblastoma [J].
Audo, I ;
Darjatmoko, SR ;
Schlamp, CL ;
Lokken, JM ;
Lindstrom, MJ ;
Albert, DM ;
Nickells, RW .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 (10) :4192-4199
[5]   Antiproliferative role of vitamin D and its analogs - a brief overview [J].
Banerjee, P ;
Chatterjee, M .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2003, 253 (1-2) :247-254
[6]   THE RAPID NONGENOMIC ACTIONS OF 1-ALPHA,25-DIHYDROXYVITAMIN-D3 MODULATE THE HORMONE-INDUCED INCREMENTS IN OSTEOCALCIN GENE-TRANSCRIPTION IN OSTEOBLAST-LIKE CELLS [J].
BARAN, DT ;
SORENSEN, AM ;
SHALHOUB, V ;
OWEN, T ;
STEIN, G ;
LIAN, J .
JOURNAL OF CELLULAR BIOCHEMISTRY, 1992, 50 (02) :124-129
[7]   Enhancement of VDR-mediated transcription by phosphorylation: Correlation with increased interaction between the VDR and DRIP205, a subunit of the VDR-interacting protein coactivator complex [J].
Barletta, F ;
Freedman, LP ;
Christakos, S .
MOLECULAR ENDOCRINOLOGY, 2002, 16 (02) :301-314
[8]   Antiproliferative effects of 1α,25-dihydroxyvitamin D3 and vitamin D analogs on tumor-derived endothelial cells [J].
Bernardi, RJ ;
Johnson, CS ;
Modzelewski, RA ;
Trump, DL .
ENDOCRINOLOGY, 2002, 143 (07) :2508-2514
[9]   Plasma 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D and risk of breast cancer [J].
Bertone-Johnson, ER ;
Chen, WY ;
Holick, MF ;
Hollis, BW ;
Colditz, GA ;
Willett, WC ;
Hankinson, SE .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (08) :1991-1997
[10]   Vitamin D: newly discovered actions require reconsideration of physiologic requirements [J].
Bikle, Daniel D. .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2010, 21 (06) :375-384
123456789