Finding the will and the way of ERAD substrate retrotranslocation

被引：110

作者：

Hampton, Randolph Y. ^{[1
]}

Sommer, Thomas ^{[2
,3
]}

机构：

[1] UCSD, Div Biol Sci, Sect Cell & Dev Biol, La Jolla, CA 92093 USA

[2] Max Delbruck Ctr Mol Med, D-13122 Berlin, Germany

[3] Humboldt Univ, Inst Biol, D-10099 Berlin, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 2012年 / 24卷 / 04期

关键词：

RETICULUM-ASSOCIATED DEGRADATION; UBIQUITIN-PROTEASOME PATHWAY; PROTEIN-QUALITY CONTROL; ENDOPLASMIC-RETICULUM; AAA-ATPASE; MEMBRANE-PROTEIN; RETRO-TRANSLOCATION; LIPID DROPLETS; LIGASE; DISLOCATION;

D O I：

10.1016/j.ceb.2012.05.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ER-associated degradation (ERAD) is a mechanism by which numerous ER-localized proteins are targeted for cytosolic degradation by the ubiquitin-proteasome system. A surprising and still-cryptic requirement of this process is the energy dependent retrotranslocation of both lumenal and membrane-embedded ER proteins into the cytosol for ongoing ubiquitination and proteasomal destruction. The current understanding, results, and open questions are discussed below for this intriguing and critical process of ERAD.

引用

页码：460 / 466

页数：7

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