The expression and role of CXC chemokines in colorectal cancer

被引：107
|
作者：
Verbeke, Hannelien [1 ]
Struyf, Sofie [1 ]
Laureys, Genevieve [2 ]
Van Damme, Jo [1 ]
机构：
[1] Univ Leuven KU Leuven, Rega Inst Med Res, Lab Mol Immunol, B-3000 Louvain, Belgium
[2] Ghent Univ Hosp, Kinderziekenhuis Prinses Elisabeth, Dept Pediat Hematooncol & Stem Cell Transplantat, Ghent, Belgium
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2011年 / 22卷 / 5-6期
关键词：
Angiogenesis; Chemokine; Colorectal cancer; Leukocyte; HUMAN COLON-CARCINOMA; INTESTINAL EPITHELIAL-CELLS; GRANULOCYTE CHEMOTACTIC PROTEIN-2; NEUTROPHIL-ACTIVATING PROPERTIES; GAMMA-INDUCIBLE PROTEIN-10; ENDOTHELIAL GROWTH-FACTOR; LYMPH-NODE METASTASIS; KAPPA-B ACTIVATION; GENE-EXPRESSION; TUMOR-GROWTH;
D O I：
10.1016/j.cytogfr.2011.09.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer is a life-threatening disease world-wide and colorectal cancer is the second common cause of cancer mortality. The interaction between tumor cells and stromal cells plays a crucial role in tumor initiation and progression and is partially mediated by chemokines. Chemokines predominantly participate in the chemoattraction of leukocytes to inflammatory sites. Nowadays, it is clear that CXC chemokines and their receptors (CXCR) may also modulate tumor behavior by several important mechanisms: regulation of angiogenesis, activation of a tumor-specific immune response by attracting leukocytes, stimulation of tumor cell proliferation and metastasis. Here, we review the expression and complex roles of CXC chemokines (CXCL1 to CXCL16) and their receptors (CXCR1 to CXCR6) in colorectal cancer. Overall, increased expression levels of CXC chemokines correlate with poor prognosis. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：345 / 358
页数：14
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