Association of Suboptimal Antiretroviral Therapy Adherence With Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study

被引：14

作者：

Castillo-Mancilla, Jose R. ^{[1
]}

Phillips, Andrew N. ^{[2
]}

Neaton, James D. ^{[3
]}

Neuhaus, Jacqueline ^{[3
]}

Collins, Simon ^{[4
]}

Mannheimer, Sharon ^{[5
]}

Pett, Sarah ^{[6
,7
]}

Touzeau-Roemer, Veronique ^{[8
]}

Polizzotto, Mark N. ^{[7
]}

Lundgren, Jens D. ^{[9
]}

Gardner, Edward M. ^{[10
]}

机构：

[1] Univ Colorado AMC, Med Infect Dis, Aurora, CO USA

[2] UCL, Inst Global Hlth, London, England

[3] Univ Minnesota, Sch Publ Hlth, Minneapolis, MN USA

[4] HIV I Base, London, England

[5] Columbia Univ, Med Ctr, Harlem Hosp Ctr, New York, NY USA

[6] UCL, London, England

[7] Univ New South Wales, Kirby Inst, Sydney, NSW, Australia

[8] Univ Vienna, Div Immunol Allergy & Infect Dis, AKH, Sch Med, Vienna, Austria

[9] Rigshosp, CHIP, Dept Infect Dis, Copenhagen, Denmark

[10] Denver Hlth, Med Ctr, Denver, CO USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2018年 / 5卷 / 01期

关键词：

adherence; antiretroviral therapy; inflammation; SMART study; MONOCYTE ACTIVATION; HIV; COAGULATION; MARKERS; BIOMARKERS; PREDICTOR; MORTALITY;

D O I：

10.1093/ofid/ofx275

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Suboptimal (ie, <100%) antiretroviral therapy (ART) adherence has been associated with heightened inflammation in cohort studies, even among people with virologic suppression. We aimed to evaluate this association among participants in the Strategies for Management of Antiretroviral Therapy (SMART) study who had virologic suppression (HIV-1 VL <200 copies/mL) at enrollment. Based on self-reported adherence (7-day recall), plasma concentrations of interleukin 6 and D-dimer were 9% (95% confidence interval [CI], 1%-18%; P = .02) and 11% (95% CI, 1%-22%; P = .03) higher in participants who reported suboptimal vs 100% adherence, respectively. These findings confirm previous observations and support the hypothesis that suboptimal ART adherence, even in the context of virologic suppression, may have significant biological consequences.

引用

页数：5

共 20 条

[1] Interleukin 6 Is a Stronger Predictor of Clinical Events Than High-Sensitivity C-Reactive Protein or D-Dimer During HIV Infection [J].

Borges, Alvaro H. ;

O'Connor, Jemma L. ;

Phillips, Andrew N. ;

Neaton, James D. ;

Grund, Birgit ;

Neuhaus, Jacqueline ;

Vjecha, Michael J. ;

Calmy, Alexandra ;

Koelsch, Kersten K. ;

Lundgren, Jens D. .

JOURNAL OF INFECTIOUS DISEASES, 2016, 214 (03) :408-416

[2] Factors Associated With Plasma IL-6 Levels During HIV Infection [J].

Borges, Alvaro H. ;

O'Connor, Jemma L. ;

Phillips, Andrew N. ;

Ronsholt, Frederikke F. ;

Pett, Sarah ;

Vjecha, Michael J. ;

French, Martyn A. ;

Lundgren, Jens D. .

JOURNAL OF INFECTIOUS DISEASES, 2015, 212 (04) :585-595

[3] Predicting risk of cancer during HIV infection: the role of inflammatory and coagulation biomarkers [J].

Borges, Alvaro H. ;

Silverberg, Michael J. ;

Wentworth, Deborah ;

Grulich, Andrew E. ;

Faetkenheuer, Gerd ;

Mitsuyasu, Ronald ;

Tambussi, Giuseppe ;

Sabin, Caroline A. ;

Neaton, James D. ;

Lundgren, Jens D. .

AIDS, 2013, 27 (09) :1433-1441

[4] Weekends-off efavirenz-based antiretroviral therapy in HIV-infected children, adolescents, and young adults (BREATHER): a randomised, open-label, non-inferiority, phase 2/3 trial [J].

Butler, Karina ;

Turkova, Anna ;

Inshaw, Jamie ;

Compagnucci, Alexandra ;

Kenny, Julia ;

Saidi, Yacine ;

Musiime, Victor ;

Nanduudu, Annett ;

Cressey, Tim R. ;

Chalermpantmetagul, Suwalai ;

Scott, Karen ;

Harper, Lynda ;

Montero, Sam ;

Riault, Yoann ;

Bunupuradah, Torsak ;

Volokha, Alla ;

Flynn, Patricia M. ;

Bologna, Rosa ;

Kizito, Hilda ;

Ramos, Jose T. ;

Nastouli, Eleni ;

Klein, Nigel ;

Giaquinto, Carlo ;

Ford, Deborah ;

Babiker, Abdel ;

Gibb, Diana M. .

LANCET HIV, 2016, 3 (09) :E421-E430

[5]

Castillo- Mancilla J, 2017, CROI FEBR 13 16 SEAT

[6] Suboptimal Adherence to Combination Antiretroviral Therapy Is Associated With Higher Levels of Inflammation Despite HIV Suppression [J].

Castillo-Mancilla, Jose R. ;

Brown, Todd T. ;

Erlandson, Kristine M. ;

Palella, Frank J., Jr. ;

Gardner, Edward M. ;

Macatangay, Bernard J. C. ;

Breen, Elizabeth C. ;

Jacobson, Lisa P. ;

Anderson, Peter L. ;

Wada, Nikolas I. .

CLINICAL INFECTIOUS DISEASES, 2016, 63 (12) :1661-1667

[7]

de Truchis P, 2017, IAS 2017 9 IAS C HIV

[8]

El-Sadr WM, 2006, NEW ENGL J MED, V355, P2283, DOI 10.1056/NEJMoa062360

[9] Differential Reduction in Monocyte Activation and Vascular Inflammation With Integrase Inhibitor-Based Initial Antiretroviral Therapy Among HIV-Infected Individuals [J].

Hileman, Corrilynn O. ;

Kinley, Bruce ;

Scharen-Guivel, Valeska ;

Melbourne, Kathy ;

Szwarcberg, Javier ;

Robinson, Janet ;

Lederman, Michael M. ;

Mccomsey, Grace A. .

JOURNAL OF INFECTIOUS DISEASES, 2015, 212 (03) :345-354

[10] Immunologic Biomarkers, Morbidity, and Mortality in Treated HIV Infection [J].

Hunt, Peter W. ;

Lee, Sulggi A. ;

Siedner, Mark J. .

JOURNAL OF INFECTIOUS DISEASES, 2016, 214 :S44-S50

← 1 2 →