Lesional Th17 cells and regulatory T cells in bullous pemphigoid

被引：100
作者：
Arakawa, Masataka
Dainichi, Teruki
Ishii, Norito
Hamada, Takahiro
Karashima, Tadashi
Nakama, Takekuni
Yasumoto, Shinichiro
Tsuruta, Daisuke
Hashimoto, Takashi [1 ]
机构：
[1] Kurume Univ, Sch Med, Dept Dermatol, Kurume, Fukuoka 8300011, Japan
来源：
EXPERIMENTAL DERMATOLOGY | 2011年 / 20卷 / 12期
关键词：
bullous pemphigoid; IL-17; pemphigus foliaceus; pemphigus vulgaris; Th17; Treg; EXPRESSION; DISEASES;
D O I：
10.1111/j.1600-0625.2011.01378.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Th17 cells play crucial roles in the pathogenesis of autoimmune diseases. We previously reported that Th17 cells are recruited to the lesional skin in pemphigus vulgaris (PV) and pemphigus foliaceus (PF). The aim of this study was to evaluate lesional Th17 cells and Treg cells in bullous pemphigoid (BP). Correlations between these cells and disease severity of BP were also evaluated. Immunohistochemical studies showed that both IL-17+ and Foxp3+ cells were present in higher numbers in BP lesions, compared with control skin. IL-17/CD4 ratio in BP was significantly higher than that in PF. Foxp3/CD4 ratio in BP was significantly less than that in either PV or PF. There were no obvious correlations between these cells and disease severity of BP. This study suggests that, compared with pemphigus, BP shows more Th17 cell-related inflammation and less Treg-related regulation.
引用
收藏
页码：1022 / 1024
页数：3
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