Metastatic malignant teratoma arising from mediastinal nonseminomatous germ cell tumor: A case report

被引：3
作者：
Collen, Jacob [1 ]
Carmichael, Mark [1 ]
Wroblewski, Tanya [1 ]
机构：
[1] Walter Reed Army Med Ctr, Washington, DC 20307 USA
来源：
MILITARY MEDICINE | 2008年 / 173卷 / 04期
关键词：
D O I：
10.7205/MILMED.173.4.406
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Primary mediastinal nonseminomatous germ cell tumors (NSGCT) have a worse prognosis than gonadal germ cell tumors (GCTs). Malignant transformation of teratomatous components of GCT to a somatic malignancy is rare. We present a case of primary mediastinal NSGCT with malignant transformation of a teratoma in an active duty airman who presented with a 12-cm anterior mediastinal mass and vertebral body lesion. Pathology confirmed NSGCT with yolk sac and teratomatous components. Chemotherapy for GCT normalized serum tumor markers with little effect on the mediastinal mass. Incomplete resection of the residual tumor revealed high-grade mixed sarcoma. Serum tumor markers rose 3 months following resection with metastatic disease to bone and liver. Chemotherapy targeting sarcoma induced a partial response, but the patient developed acute myeloid leukemia refractory to chemotherapy. We discuss our approach to management of this complicated patient.
引用
收藏
页码：406 / 409
页数：4
相关论文
共 50 条
[21]   Nonseminomatous Extragonadal Germ Cell Tumor With Teratomatous and Multiple Malignant Somatic Components: A Rare Case Report [J].
Murray, Glenn ;
Kaminsky, Joseph .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2018, 149 :S105-S106
[22]   ADULT TERATOMA AS LATE RECURRENCE OF METASTASIZED NONSEMINOMATOUS GERM-CELL TUMOR - CASE-REPORT AND CLINICAL IMPLICATIONS [J].
KUCZYK, MA ;
BOKEMEYER, C ;
FICHNA, B ;
TRUSS, M ;
SCHMOLL, HJ ;
JONAS, U .
UROLOGE-AUSGABE A, 1995, 34 (06) :480-484
[23]   Cutaneous nonseminomatous mixed extragonadal germ cell tumor: a case report [J].
Lacerda, Priscila N. ;
Campos, Luana M. ;
Barbosa, Barbara E. C. ;
Miot, Helio A. .
INTERNATIONAL JOURNAL OF DERMATOLOGY, 2022, 61 (04) :E125-E126
[24]   Malignant somatic transformation arising from teratoma in metastatic testicular germ cell tumor detected on 18F-FDG PET/CT [J].
Cardenas-Perilla, R. .
REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR, 2022, 41 :S39-S41
[25]   MULTIMODAL THERAPY FOR MEDIASTINAL NONSEMINOMATOUS GERM CELL TUMOR WITH SOMATIC-TYPE MALIGNANCY WITH BRAIN METASTASIS; REPORT OF A CASE [J].
Kamiyama, Ikuo ;
Tsukada, Norimasa ;
Sawafuji, Makoto .
JOURNAL OF THORACIC ONCOLOGY, 2011, 6 (06) :S1454-S1455
[26]   DNA variants in teratomatous and embryonal components of primary mediastinal nonseminomatous germ cell tumor: a case report and literature review [J].
Tran, Jessica T. ;
Chea, Metha R. ;
Sachdev, Koushalya ;
Peterson, Joshua M. ;
Huang, Gengming ;
Han, Song ;
Lin, Youmin ;
Han, Bryan ;
Olano, Juan ;
Dong, Jianli .
LABORATORY MEDICINE, 2025,
[27]   MALIGNANT MEDIASTINAL GERM-CELL TUMOR [J].
GALE, G .
MEDICAL AND PEDIATRIC ONCOLOGY, 1981, 9 (04) :375-380
[28]   Malignant Melanoma Arising in a Primary Mediastinal Teratoma: Case Report of a Rare Phenomenon and Review of the Literature [J].
Khafateh, Youssef ;
Preciado, Christopher ;
Elder, David E. ;
Litzky, Leslie A. ;
Vaughn, David J. ;
Singhal, Sunil ;
Lal, Priti ;
Palmer, Matthew B. .
AJSP-REVIEWS AND REPORTS, 2022, 27 (01) :33-36
[29]   High rate of retroperitoneal teratoma despite complete remission after chemotherapy for metastatic nonseminomatous germ cell tumor [J].
Steiner, H. ;
Akkad, T. ;
Gozzi, C. ;
Springer-Stoehr, B. ;
Bartsch, G. .
EUROPEAN UROLOGY SUPPLEMENTS, 2007, 6 (02) :157-157
[30]   High rate of retroperitoneal teratoma despite complete remission after chemotherapy for metastatic nonseminomatous germ cell tumor [J].
Steiner, Hannes ;
Akkad, Thomas ;
Gozzi, Christian ;
Bartsch, Georg .
JOURNAL OF UROLOGY, 2007, 177 (04) :277-277
12345