An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

被引：815
作者：
Eberl, G
Marmon, S
Sunshine, MJ
Rennert, PD
Choi, YW
Littman, DR
机构：
[1] NYU, Sch Med, Mol Pathogenesis Program, New York, NY 10016 USA
[2] NYU, Sch Med, Howard Hughes Med Inst, Skirball Inst Biomol Med, New York, NY 10016 USA
[3] Biogen Inc, Dept Immunol, Cambridge, MA 02142 USA
[4] Univ Penn, Sch Med, Abramson Family Canc Res Inst, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
来源：
NATURE IMMUNOLOGY | 2004年 / 5卷 / 01期
关键词：
D O I：
10.1038/ni1022
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORgammat is expressed exclusively in and is required for the generation of LTi cells. RORgammat(+) LTi cells provide essential factors, among which lymphotoxin-alpha(1)beta(2) is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues.
引用
收藏
页码：64 / 73
页数：10
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