Gold-Catalyzed Regioselective Synthesis of Pyrazolo[1,4]oxazepines via Intramolecular7-endo-digCyclization

被引：11

作者：

Thummala, Yadagiri ^{[1
,2
]}

Raju, Chittala Emmaniel ^{[1
,2
]}

Purnachandar, Dalovai ^{[1
,2
]}

Sreenivasulu, Gottam ^{[1
,2
]}

Doddi, Venkata Ramana ^{[3
]}

Karunakar, Galla V. ^{[1
,2
]}

机构：

[1] CSIR, Indian Inst Chem Technol, Fluoro & Agrochem Dept, Hyderabad 500007, India

[2] Acad Sci & Innovat Res, Ghaziabad 201002, India

[3] Cent Univ Karnataka, Dept Chem & Chem Sci, Kadaganchi 585367, Karnataka, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 24期

关键词：

Gold catalysis; 7-endo digCyclization; Pyrazolo[1; 4]Oxazepines; C-N bond formation; PROPARGYLIC BETA-ENAMINONES; INTRAMOLECULAR CYCLIZATION; ASYMMETRIC INDUCTION; FACILE FORMATION; DERIVATIVES; AMOXAPINE; DESIGN; ACIDS; ISOMERIZATION; ACHIEVEMENTS;

D O I：

10.1002/ejoc.201901852

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient gold-catalyzed intramolecular regioselective synthesis of pyrazolo[1,4]oxazepines were developed from alkynyl-substituted pyrazoles via7-endo digcyclization. In this reaction a new C-N bond was formed and substituted pyrazolo[1,4]oxazepines were obtained in moderate to very good yields. Whereas alkynyl-substituted pyrazoles treated with sodium hydride produced the corresponding pyrazolo[1,4]oxazines regioselectively, via6-exo digcyclization in one-pot synthesis.

引用

页码：3560 / 3567

页数：8

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