The Role of Gut Microbiota Biomodulators on Mucosal Immunity and Intestinal Inflammation

被引：185

作者：

Amoroso, Chiara ^{[1
]}

Perillo, Federica ^{[1
]}

Strati, Francesco ^{[1
]}

Fantini, Massimo ^{[2
,3
]}

Caprioli, Flavio ^{[4
,5
]}

Facciotti, Federica ^{[1
]}

机构：

[1] IEO European Inst Oncol IRCCS, Dept Expt Oncol, I-20139 Milan, Italy

[2] AOU Cagliari, Duilio Casula Hosp, Gastroenterol Unit, I-09042 Cagliari, Italy

[3] Univ Cagliari, Dept Med Sci & Publ Hlth, I-09124 Cagliari, Italy

[4] Univ Milan, Dept Pathophysiol & Transplantat, I-20135 Milan, Italy

[5] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Gastroenterol & Endoscopy Unit, I-20135 Milan, Italy

来源：

CELLS | 2020年 / 9卷 / 05期

关键词：

inflammatory bowel diseases; gut microbiome; live biotherapeutic products; FMT; ACTIVE ULCERATIVE-COLITIS; BUTYRATE-PRODUCING BACTERIA; DSS-INDUCED COLITIS; REGULATORY T-CELLS; BOWEL-DISEASE; CROHNS-DISEASE; PROBIOTIC MIXTURE; DENDRITIC CELLS; NISSLE; 1917; TRANSPLANTATION;

D O I：

10.3390/cells9051234

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alterations of the gut microbiota may cause dysregulated mucosal immune responses leading to the onset of inflammatory bowel diseases (IBD) in genetically susceptible hosts. Restoring immune homeostasis through the normalization of the gut microbiota is now considered a valuable therapeutic approach to treat IBD patients. The customization of microbe-targeted therapies, including antibiotics, prebiotics, live biotherapeutics and faecal microbiota transplantation, is therefore considered to support current therapies in IBD management. In this review, we will discuss recent advancements in the understanding of host-microbe interactions in IBD and the basis to promote homeostatic immune responses through microbe-targeted therapies. By considering gut microbiota dysbiosis as a key feature for the establishment of chronic inflammatory events, in the near future it will be suitable to design new cost-effective, physiologic, and patient-oriented therapeutic strategies for the treatment of IBD that can be applied in a personalized manner.

引用

页数：24

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