Depth-resolved measurement of mucosal microvascular blood content using low-coherence enhanced backscattering spectroscopy

被引：7

作者：

Radosevich, Andrew J. ^{[1
]}

Turzhitsky, Vladimir M. ^{[1
]}

Mutyal, Nikhil N. ^{[1
]}

Rogers, Jeremy D. ^{[1
]}

Stoyneva, Valentina ^{[1
]}

Tiwari, Ashish Kumar ^{[2
]}

De La Cruz, Mart ^{[2
]}

Kunte, Dhananjay P. ^{[2
]}

Wali, Ramesh K. ^{[2
]}

Roy, Hemant K. ^{[2
]}

Backman, Vadim ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[2] Northshore Univ Healthsyst, Dept Gastroenterol, Evanston, IL 60201 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2010年 / 1卷 / 04期

基金：

美国国家卫生研究院;

关键词：

DIFFUSE-REFLECTANCE SPECTROSCOPY; POLARIZED-LIGHT TRANSPORT; MONTE-CARLO PROGRAMS; OPTICAL-PROPERTIES; SCATTERING MEDIA;

D O I：

10.1364/BOE.1.001196

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Low-coherence enhanced backscattering (LEBS) spectroscopy is a light scattering technique which uses partial spatial coherence broadband illumination to interrogate the optical properties at sub-diffusion length scales. In this work, we present a post-processing technique which isolates the hemoglobin concentration at different depths within a sample using a single spectroscopic LEBS measurement with a fixed spatial coherence of illumination. We verify the method with scattering (spectralon reflectance standard and polystyrene microspheres) and absorbing (hemoglobin) phantoms. We then demonstrate the relevance of this method for quantifying hemoglobin content as a function of depth within biological tissue using the azoxymethane treated animal model of colorectal cancer. (C)2010 Optical Society of America

引用

页码：1196 / 1208

页数：13

共 33 条

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Kim, YL
Liu, Y
Turzhitsky, VM
Wali, RK
Roy, HK
Backman, V
OPTICS LETTERS, 2005, 30 (07) : 741 - 743
[2] Depth-resolved measurement of ocular fundus pulsations by low-coherence tissue interferometry
Dragostinoff, Nikolaus
Werkmeister, Rene M.
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Schmetterer, Leopold
JOURNAL OF BIOMEDICAL OPTICS, 2009, 14 (05)
[3] Depth-resolved low-coherent backscattering spectroscopy
Kim, YL
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Turzhitsky, V
Wali, RK
Roy, HK
Backman, V
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX, 2005, 5690 : 297 - 307
[4] Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy
Turzhitsky, Vladimir
Radosevich, Andrew J.
Rogers, Jeremy D.
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JOURNAL OF BIOMEDICAL OPTICS, 2011, 16 (06)
[5] Multiple scattering model for the penetration depth of low-coherence enhanced backscattering
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JOURNAL OF BIOMEDICAL OPTICS, 2011, 16 (09)
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Subramanian, Hariharan
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APPLIED OPTICS, 2006, 45 (24) : 6292 - 6300
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JOURNAL OF BIOMEDICAL OPTICS, 2011, 16 (01)
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Mutyal, Nikhil N.
Radosevich, Andrew
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Rogers, Jeremy D.
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OPTICS EXPRESS, 2012, 20 (18): : 19643 - 19657

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