Disseminated intravascular coagulation as the presenting sign of gastric cancer during pregnancy

被引：8

作者：

Takai, Hiroshi ^{[1
]}

Kondoh, Eiji ^{[1
]}

Sato, Yukiyasu ^{[1
]}

Kakui, Kazuyo ^{[1
]}

Tatsumi, Keiji ^{[1
]}

Konishi, Ikuo ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Gynecol & Obstet, Sakyo Ku, Kyoto 6068507, Japan

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2011年 / 37卷 / 11期

关键词：

bone metastasis; disseminated intravascular coagulation (DIC); diagnosis; gastric cancer; pregnancy;

D O I：

10.1111/j.1447-0756.2011.01561.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Gastric cancer during pregnancy is rare and the outcome is generally poor. A 36-year-old woman in the 28th week of gestation was complicated with disseminated intravascular coagulation (DIC), and she was diagnosed with gastric cancer with bone marrow metastasis. Cesarean delivery followed by sequential methotrexate (100 mg/m2) and 5-fluorouracil (600 mg/m2) chemotherapy was conducted. DIC was successfully managed with blood transfusion and chemotherapy. She has received chemotherapy in the outpatient clinic. This report is the second case of a pregnant woman with DIC as the initial manifestation of advanced gastric cancer. Prompt diagnosis and chemotherapy increases the chances of a relatively favorable outcome even in advanced gastric cancer presenting with DIC due to bone marrow involvement.

引用

页码：1717 / 1719

页数：3

共 8 条

[1] Use of chemotherapy during human pregnancy [J].

Cardonick, E ;

Iacobucci, A .

LANCET ONCOLOGY, 2004, 5 (05) :283-291

[2] Sequential methotrexate and 5-fluorouracil therapy for gastric cancer patients with bone metastasis [J].

Hironaka S.-I. ;

Boku N. ;

Ohtsu A. ;

Nagashima F. ;

Sano Y. ;

Muto M. ;

Fujii T. ;

Tajiri H. ;

Yoshida S. .

Gastric Cancer, 2000, 3 (1) :19-23

[3] Gastric cancer in pregnancy: Do pregnancy, age or female sex alter the prognosis? Case reports and review [J].

Jaspers, VKI ;

Gillessen, A ;

Quakernack, K .

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1999, 87 (01) :13-22

[4] Advanced gastric cancer and a concomitant pregnancy associated with disseminated intravascular coagulation [J].

Kurabayashi, T ;

Isii, K ;

Suzuki, M ;

Takakuwa, K ;

Shibazaki, Y ;

Ozawa, T ;

Narisawa, R ;

Sekizuka, N ;

Tanaka, K .

AMERICAN JOURNAL OF PERINATOLOGY, 2004, 21 (05) :295-298

[5] Clinical Characteristics of Gastric Cancer Associated with Pregnancy [J].

Lee, Hyuk-Joon ;

Lee, In Kyu ;

Kim, Jong Won ;

Lee, Kuhn Uk ;

Choe, Kuk Jin ;

Yang, Han-Kwang .

DIGESTIVE SURGERY, 2009, 26 (01) :31-36

[6]

PASQUINI E, 1995, ONCOLOGY, V52, P505

[7] Management of patients with pregnancy-associated gastric cancer in Japan: a mini-review [J].

Sakamoto, Kaoru ;

Kanda, Tatsuo ;

Ohashi, Manabu ;

Kurabayashi, Takumi ;

Serikawa, Takehiro ;

Matsunaga, Masamichi ;

Hatakeyama, Katsuyoshi .

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2009, 14 (05) :392-396

[8] Sequential chemotherapy with methotrexate and 5-fluorouracil for chemotherapy-naive advanced gastric cancer with disseminated intravascular coagulation at initial diagnosis [J].

Takashima, Atsuo ;

Shirao, Kuniaki ;

Hirashima, Yoshinori ;

Takahari, Daisuke ;

Okita, Natsuko T. ;

Nakajima, Takako E. ;

Kato, Ken ;

Hamaguchi, Tetsuya ;

Yamada, Yasuhide ;

Shimada, Yasuhiro .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2010, 136 (02) :243-248

← 1 →