Retention of γH2AX foci as an indication of lethal DNA damage

被引：64
|
作者：
Olive, Peggy L.
机构：
[1] British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3
来源：
RADIOTHERAPY AND ONCOLOGY | 2011年 / 101卷 / 01期
基金：
加拿大健康研究院;
关键词：
gamma H2AX; DNA damage; Prediction; Tumour response; DOUBLE-STRAND BREAKS; PHOSPHORYLATED HISTONE H2AX; CANCER CELL-LINES; TUMOR-CELLS; RADIATION SENSITIVITY; RESIDUAL GAMMA-H2AX; MAMMALIAN-CELLS; LUNG-CANCER; REPAIR FOCI; RADIOSENSITIVITY;
D O I：
10.1016/j.radonc.2011.05.055
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The application of biological responses of tumours to predict clinical responses to treatment represents a challenging goal with the potential to inform treatment decisions and improve outcome. If tumour cell death is the result of the inability of a cell to repair complex DNA damage, and if gamma H2AX foci mark sites of unrepaired double-strand breaks, then it may be possible to use residual gamma H2AX foci to identify treatment-resistant tumour cells early in the course of therapy. This review will highlight some of the evidence that supports the idea that residual gamma H2AX foci, within certain limitations, may be useful as an early indicator of tumour response to radiotherapy in situ, either alone or in combination with chemotherapy. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 101 (2011) 18-23
引用
收藏
页码：18 / 23
页数：6
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