Compounds from Arnebia euchroma and Their Related Anti-HCV and Antibacterial Activities

被引：63

作者：

Li, Hong-Mei ^{[1
]}

Tang, Ying-Lei ^{[1
]}

Zhang, Zhong-Hua ^{[1
]}

Liu, Chen-Jian ^{[1
]}

Li, Hai-Zhou ^{[1
]}

Li, Rong-Tao ^{[1
]}

Xia, Xue-Shan ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Coll Life Sci & Technol, Kunming 650224, Yunnan, Peoples R China

来源：

PLANTA MEDICA | 2012年 / 78卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Arnebia euchroma; Boraginaceae; hydroquinone terpenoids; monoterpenylbenzenoid; anti-HCV activity; antibacterial activity; HEPATITIS-C VIRUS; NATURALLY-OCCURRING QUINONES; REPLICATION;

D O I：

10.1055/s-0031-1280266

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A-C (1-3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of Arnebia euchroma. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and compounds 1, 6, and des-O-methyllasiodiplodin (7) showed anti-Staphylococcus aureus activity with MICs of 0.5, 0.125, and 0.125 mg/mL, respectively.

引用

页码：39 / 45

页数：7

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