Clinical Management of Thrombotic Antiphospholipid Syndrome

被引：23

作者：

Tumian, Nor Rafeah ^{[1
,2
]}

Hunt, Beverley J. ^{[1
]}

机构：

[1] Guys & St Thomas Hosp NHS Fdn Trust, Haemostasis & Thrombosis Ctr, Westminster Bridge Rd, London SE1 7EH, England

[2] Univ Kebangsaan Malaysia, Dept Med, Clin Haematol Unit, Fac Med,Med Ctr, Kuala Lumpur 56000, Malaysia

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 03期

关键词：

antiphospholipid syndrome; autoimmune; acquired thrombophilia; thrombosis; SYSTEMIC-LUPUS-ERYTHEMATOSUS; INTERNATIONAL CONSENSUS STATEMENT; ANTIBODY SYNDROME; CLASSIFICATION CRITERIA; ASYMPTOMATIC CARRIERS; RECURRENT THROMBOSIS; I INTERFERON; RISK-FACTORS; MULTICENTER; PREVENTION;

D O I：

10.3390/jcm11030735

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombotic manifestations of antiphospholipid syndrome are often a therapeutic dilemma and challenge. Despite our increasing knowledge of this relatively new disease, many issues remain widely unknown and controversial. In this review, we summarise the latest literature and guidelines on the management of thrombotic antiphospholipid syndrome. These include the laboratory assays involved in antiphospholipid antibodies (aPL) testing, the use of direct oral anticoagulants in secondary prevention, management of recurrent thrombosis, individuals with isolated aPL, and catastrophic antiphospholipid syndrome. Treatment aims to prevent the potentially fatal and often disabling complications of APS with antithrombotic and cardiovascular risks prevention strategies. Some insights and updates on topical issues in APS are provided. We also include our current practice, which we believe is the pragmatic approach based on the currently available evidence.

引用

页数：13

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