Ski and SnoN:: negative regulators of TGF-β signaling

被引：169
作者：
Luo, KX
机构：
[1] Lawrence Berkeley Natl Lab, Div Life Sci, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/j.gde.2003.11.003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ski and SnoN are unique proto-oncoproteins in that they can induce both oncogenic transformation and terminal muscle differentiation when expressed at high levels. Recent studies using in vitro and in vivo approaches have begun to unravel the complex roles of Ski and SnoN in tumorigenesis and embryonic development. The identification of Ski and SnoN as important negative regulators of signal transduction by the transforming growth factor-beta superfamily of cytokines provides a valuable molecular basis for the complex functions of Ski and SnoN.
引用
收藏
页码：65 / 70
页数：6
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  • [1] c-Ski acts as a transcriptional co-repressor in transforming growth factor-β signaling through interaction with Smads
    Akiyoshi, S
    Inoue, H
    Hanai, J
    Kusanagi, K
    Nemoto, N
    Miyazono, K
    Kawabata, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (49) : 35269 - 35277
  • [2] Autonomous neural axis formation by ectopic expression of the protooncogene c-ski
    Amaravadi, LS
    Neff, AW
    Sleeman, JP
    Smith, RC
    [J]. DEVELOPMENTAL BIOLOGY, 1997, 192 (02) : 392 - 404
  • [3] Barlow AJ, 1997, DEVELOPMENT, V124, P391
  • [4] Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial patterning, and skeletal muscle development
    Berk, M
    Desai, SY
    Heyman, HC
    Colmenares, C
    [J]. GENES & DEVELOPMENT, 1997, 11 (16) : 2029 - 2039
  • [5] TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation
    Bonni, S
    Wang, HR
    Causing, CG
    Kavsak, P
    Stroschein, SL
    Luo, KX
    Wrana, JL
    [J]. NATURE CELL BIOLOGY, 2001, 3 (06) : 587 - 595
  • [6] BOYER PL, 1993, ONCOGENE, V8, P457
  • [7] Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice
    Colmenares, C
    Heilstedt, HA
    Shaffer, LG
    Schwartz, S
    Berk, M
    Murray, JC
    Stavnezer, E
    [J]. NATURE GENETICS, 2002, 30 (01) : 106 - 109
  • [8] ACTIVATION OF THE C-SKI ONCOGENE BY OVEREXPRESSION
    COLMENARES, C
    SUTRAVE, P
    HUGHES, SH
    STAVNEZER, E
    [J]. JOURNAL OF VIROLOGY, 1991, 65 (09) : 4929 - 4935
  • [9] THE SKI ONCOGENE INDUCES MUSCLE DIFFERENTIATION IN QUAIL EMBRYO CELLS
    COLMENARES, C
    STAVNEZER, E
    [J]. CELL, 1989, 59 (02) : 293 - 303
  • [10] Transformation of hematopoietic cells by the Ski oncoprotein involves repression of retinoic acid receptor signaling
    Dahl, R
    Kieslinger, M
    Beug, H
    Hayman, MJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (19) : 11187 - 11192
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