[Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinyl-bis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities

被引：7
作者：
Gust, R
Heinrich, H
Krauser, R
Schönenberger, H
机构：
[1] FU Berlin, Inst Pharm 1, D-14195 Berlin, Germany
[2] Univ Regensburg, Inst Pharm, Lehrstuhl Pharmazeut Chem 2, D-93040 Regensburg, Germany
来源：
INORGANICA CHIMICA ACTA | 1999年 / 285卷 / 02期
关键词：
antitumor activity; platinum complexes; diammine complexes; sulfinyl complexes;
D O I：
10.1016/S0020-1693(98)00326-0
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis, the physiochemical and the breast cancer inhibiting properties of [meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chlorides(meso- and rac-4F-PtCl(DMSO)) are described, Rac-4F-PtCl(DMSO) surpasses the standard carboplatin in its effect on the human MCF-7 breast cancer cell line and is more resistant than its: dichloroplatinum(II) analogue rac-4F-PtCl2 against attack of nucleophiles, a prerequisite for sufficient stability in physiological environments and consequently for marked antitumor activity in vivo. [GRAPHICS] (C) 1999 Elsevier Science S.A. All rights reserved.
引用
收藏
页码：184 / 189
页数：6
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