Preservation of non-heart-beating donor livers in extracorporeal liver perfusion and histidine-trytophan-ketoglutarate solution

被引：9

作者：

Gong, Jin ^{[1
]}

Lao, Xue-Jun ^{[1
]}

Wang, Xi-Mo ^{[2
]}

Long, Gang ^{[2
]}

Jiang, Tao ^{[2
]}

Chen, Shi ^{[3
]}

机构：

[1] Jinan Univ, Dept Surg, Affiliated Hosp 1, Guangzhou 510630, Guangdong, Peoples R China

[2] Tianjin Peoples Hosp, Dept Surg, Tianjin 300120, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Organ Transplantat, Tongji Med Coll, Wuhan 430030, Hubei Province, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 15期

关键词：

extracorporeal liver perfusion; histidine-trytophan-ketoglutarate solution; non-heart-beating donor; preservation;

D O I：

10.3748/wjg.14.2338

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To compare the preservation of non-heart-beating donor (NHBD) livers in cold histidine-trytophan-ketoglutarate (HTK) solution and extracorporeal liver perfusion (ECLP). METHODS: Livers harvested from health pigs were stored for 10 h in cold HTK solution (group A, n = 4) or perfused with oxygenated autologous blood at body temperature (group B, n = 4). Both groups were then tested on the circuit for 4 h. Bile production, hemodynamic parameters, hepatocyte markers and reperfusion injury of extracorporeal livers were tested in each group. Liver tissues from each group were examined at the end of reperfusion. RESULTS: At 1, 2, 3 and 4 h after reperfusion, bile production, hemodynamic parameters, hepatocyte markers and reperfusion injury of livers in group A were statistically different from those in group B (P < 0.05 or P < 0.01). CONCLUSION: ECLP is better than HTK solution to preserve NHBD livers. ECLP can assess the graft viability before liver transplantation. (c) 2008 WJG. All rights reserved.

引用

页码：2338 / 2342

页数：5

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