Serine Metabolism: Some Tumors Take the Road Less Traveled

被引：90

作者：

DeBerardinis, Ralph J. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, McDermott Ctr Human Growth & Dev, Dallas, TX 75390 USA

来源：

CELL METABOLISM | 2011年 / 14卷 / 03期

关键词：

D O I：

10.1016/j.cmet.2011.08.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer cells display a reprogramming of metabolism that facilitates growth but addicts them to key enzyme activities. Two studies in Nature and Nature Genetics find that the gene encoding the serine biosynthetic enzyme phosphoglycerate dehydrogenase (PHGDH) is amplified in a subset of cancers and contributes to tumor cell growth.

引用

页码：285 / 286

页数：2

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