SEPARATION OF NON-NATURAL AMIDE AMINO ACID ENANTIOMERS BY CAPILLARY ELECTROPHORESIS WITH CM-β-CDs AS CHIRAL SELECTIVE REAGENT

被引：0

作者：

Yang, Xiao-Dan ^{[1
]}

Li, Bao-Hui ^{[1
]}

机构：

[1] North China Elect Power Univ, Coll Environm Sci & Engineer, Baoding 071003, Hebei Province, Peoples R China

来源：

OXIDATION COMMUNICATIONS | 2016年 / 39卷 / 2A期

基金：

中国国家自然科学基金;

关键词：

capillary electrophoresis; carboxymethyl-beta-cyclodextrin; non-natural amido amino acid; STATIONARY PHASES; DERIVATIVES; CYCLODEXTRIN; CE; RESOLUTION; COMPLEX; HPLC;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Separation method of seven kinds of enantiomers of non-natural amide amino acid with a capillary electrophoresis (CE) was built while carboxymethyl-beta-cyclodextrins (CM-beta-CDs) acted as chiral selective reagent. Several different beta-CD derivatives were tested for the chiral separation of non-natural amide amino acid, and it was proved that CM-beta-CDs had an advantage of chiral selectivity for amide amino acids. Seven kinds of enantiomers of amide amino acids were separated by CE in a 50 mu m i.d. X 60 cm (effective length 45 cm) fused-silica capillary at 20 kV. 10 mM NaH2PO4 solution was served as running buffer with 10 mM CM-beta-CDs as selective reagent. The detection wavelength was set at 214 nm.

引用

页码：1875 / 1884

页数：10

共 18 条

[1] Chiral recognition:: Design and preparation of chiral stationary phases using selectors derived from Ugi multicomponent condensation reactions and a combinatorial approach [J].

Brahmachary, E ;

Ling, FH ;

Svec, F ;

Fréchet, JMJ .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2003, 5 (04) :441-450

[2] DIRECT CHIRAL HPLC SEPARATION OF THE ENANTIOMERS OF FLUORINATED N-ARYLAMINO-1-ARYLMETHYLPHOSPHONATE ESTERS - SUBSTITUENT EFFECTS ON THE ENANTIOSELECTIVITY [J].

CACCAMESE, S ;

PRINCIPATO, G ;

GRUSS, U ;

HAGELE, G ;

FAILLA, S .

TETRAHEDRON-ASYMMETRY, 1994, 5 (01) :141-148

[3] Synthesis of selectively permodified γ-cyclodextrins.: A new set of chiral stationary phases in capillary GC. [J].

Cravotto, G ;

Palmisano, G ;

Panza, L ;

Tagliapietra, S .

JOURNAL OF CARBOHYDRATE CHEMISTRY, 2000, 19 (09) :1235-1245

[4]

Dai RJ, 1998, ACTA CHIM SINICA, V56, P594

[5] Enantiomeric determination of chiral persistent organic pollutants and their metabolites [J].

Eljarrat, E. ;

Guerra, P. ;

Barcelo, D. .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2008, 27 (10) :847-861

[6] Chiral separation of N-imidazole derivatives aromatase inhibitors, by cyclodextrin-capillary zone electrophoresis.: Mechanism of enantioselective recognition [J].

Foulon, C ;

Danel, C ;

Vaccher, MP ;

Bonte, JP ;

Vaccher, C ;

Jean-François, J .

ELECTROPHORESIS, 2004, 25 (16) :2735-2744

[7]

Gao RY, 1999, CHINESE J CHEM, V17, P92

[8] Chiral resolution of tryptophan derivatives by CE using canine serum albumin and bovine serum albumin as chiral selectors [J].

Hoedl, Heike ;

Koidl, Julia ;

Schmid, Martin G. ;

Guebitz, Gerald .

ELECTROPHORESIS, 2006, 27 (23) :4755-4762

[9]

Jin JY, 2008, B KOREAN CHEM SOC, V29, P491

[10]

Lee S, 2004, B KOREAN CHEM SOC, V25, P216

← 1 2 →